300-87-8Relevant articles and documents
Styrylisoxazole-based fluorescent probes for the detection of hydrogen sulfide
Katla, Jagadish,Kanvah, Sriram
, p. 42 - 50 (2018)
Styrylisoxazoles bearing a nitro group linked to bulky aromatic rings have been synthesized and examined for their absorption and emission studies in organic solvents and water. The molecules showed emission in the visible region with significant solvatochromic emission shifts influenced by the extended conjugation of aromatic rings and intramolecular charge transfer. These absorption and emission changes were used for the efficient and sensitive detection of trace concentrations of hydrogen sulfide (H2S) through the reduction of the nitro group to the amine group in the presence of aqueous sodium sulfide. The experimental results indicated that the probes exhibit an excellent emission response with large shifts in the emission and sensitivity with a micromolar detection limit.
Development of Gold-catalyzed [4+1] and [2+2+1]/[4+2] Annulations between Propiolate Derivatives and Isoxazoles
Sahani, Rajkumar Lalji,Liu, Rai-Shung
supporting information, p. 1026 - 1030 (2017/01/18)
Two new gold-catalyzed annulations of isoxazoles with propiolates have been developed. Most isoxazoles follow an initial O attack on the alkyne to afford a [4+1] annulation product. This process results in a remarkable alkyne cleavage of initial propiolates. Unsubstituted isoxazoles proceed through an N attack step to yield formal [2+2+1]/[4+2] annulation products. These two annulation products arise initially from two seven-membered heterocyclic intermediates, which then lead to products.
Development and Scale-up of an Organocatalytic Enantioselective Process to Manufacture (S)-Pregabalin
Moccia, Maria,Cortigiani, Mauro,Monasterolo, Claudio,Torri, Federica,Del Fiandra, Claudia,Fuller, Geoffrey,Kelly, Brian,Adamo, Mauro F. A.
, p. 1274 - 1281 (2015/09/28)
Herein is reported the development of a new process to manufacture (S)-pregabalin. The method comprises six steps, run under the catalysis of a recyclable polymer bound phase transfer catalyst, and afforded (S)-pregabalin in overall 54% yield, starting from building blocks acetylacetone, isovaleraldehyde, and nitromethane.