2-N-methyl-2-N-phenyl-6-{5-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine

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Chemical Name:2-N-methyl-2-N-phenyl-6-{5-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine
CAS No.:1366660-84-5
Molecular Formula:C₂₂H₂₃N₉O
Molecular Weight:429.484
Hs Code.:

Synonyms:2-N-methyl-2-N-phenyl-6-{5-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine

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Chemical Property of 2-N-methyl-2-N-phenyl-6-{5-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine

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Technology Process of 2-N-methyl-2-N-phenyl-6-{5-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine

There total 4 articles about 2-N-methyl-2-N-phenyl-6-{5-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 123-75-1
pyrrolidine

: 1366660-86-7
[5-(3-{4-amino-6-[methyl(phenyl)amino]-1,3,5-triazin-2-yl}-1,2,4-oxadiazol-5-yl)pyridin-2-yl]methanol

: 1366660-84-5
2-N-methyl-2-N-phenyl-6-{5-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine

Guidance literature:: [5-(3-{4-amino-6-[methyl(phenyl)amino]-1,3,5-triazin-2-yl}-1,2,4-oxadiazol-5-yl)pyridin-2-yl]methanol; With methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere;

pyrrolidine; With triethylamine; In dichloromethane; at 20 - 35 ℃; for 18h;

Reference yield:

: 17874-76-9
6-(methoxycarbonyl)nicotinic acid

: 1366660-84-5
2-N-methyl-2-N-phenyl-6-{5-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 20 h / 20 - 100 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 40 °C / Inert atmosphere

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 - 35 °C

With sodium tetrahydroborate; oxalyl dichloride; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1366663-05-9
4-amino-N-hydroxy-6-[methyl(phenyl)amino]-1,3,5-triazine-2-carboximidamide

: 1366660-84-5
2-N-methyl-2-N-phenyl-6-{5-[6-(pyrrolidin-1-ylmethyl)pyridin-3-yl]-1,2,4-oxadiazol-3-yl}-1,3,5-triazine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: 20 h / 20 - 100 °C / Inert atmosphere

2.1: sodium tetrahydroborate / tetrahydrofuran / 17 h / 0 - 40 °C / Inert atmosphere

3.1: triethylamine; methanesulfonyl chloride / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.2: 18 h / 20 - 35 °C

With sodium tetrahydroborate; oxalyl dichloride; methanesulfonyl chloride; triethylamine; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;