Oxo-phenyl-acetic acid (1R,2S)-2-[methyl-(2-oxo-2-phenyl-acetyl)-amino]-1-phenyl-propyl ester

Base Information

• Chemical Name: Oxo-phenyl-acetic acid (1R,2S)-2-[methyl-(2-oxo-2-phenyl-acetyl)-amino]-1-phenyl-propyl ester
• CAS No.: 207223-23-2
• Molecular Formula: C₂₆H₂₃NO₅
• Molecular Weight: 429.472
• Mol file: 207223-23-2.mol

Synonyms:Oxo-phenyl-acetic acid (1R,2S)-2-[methyl-(2-oxo-2-phenyl-acetyl)-amino]-1-phenyl-propyl ester

Chemical Property of Oxo-phenyl-acetic acid (1R,2S)-2-[methyl-(2-oxo-2-phenyl-acetyl)-amino]-1-phenyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Oxo-phenyl-acetic acid (1R,2S)-2-[methyl-(2-oxo-2-phenyl-acetyl)-amino]-1-phenyl-propyl ester

There total 1 articles about Oxo-phenyl-acetic acid (1R,2S)-2-[methyl-(2-oxo-2-phenyl-acetyl)-amino]-1-phenyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

phenylglyoxylyl chloride (25726-04-9) + ephedrine hydrochloride (50-98-6) → Oxo-phenyl-acetic acid (1R,2S)-2-[methyl-(2-oxo-2-phenyl-acetyl)-amino]-1-phenyl-propyl ester (207223-23-2)

Guidance literature:

With dmap; triethyl borane; In dichloromethane;

DOI:10.1021/jo9722820

Reference yield: 80.0%

Oxo-phenyl-acetic acid (1R,2S)-2-[methyl-(2-oxo-2-phenyl-acetyl)-amino]-1-phenyl-propyl ester (207223-23-2) → (2S,5S,6R)-2-Hydroxy-4,5-dimethyl-2,6-diphenyl-morpholin-3-one (207223-18-5)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1021/jo9722820

Reference yield:

Oxo-phenyl-acetic acid (1R,2S)-2-[methyl-(2-oxo-2-phenyl-acetyl)-amino]-1-phenyl-propyl ester (207223-23-2) → (2S,5S,6R)-2-Allyl-4,5-dimethyl-2,6-diphenyl-morpholin-3-one

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NaOH / tetrahydrofuran

2: TiCl₄ / -20 °C

With sodium hydroxide; titanium tetrachloride; In tetrahydrofuran;

DOI:10.1021/jo9722820

upstream raw materials:

phenylglyoxylyl chloride

ephedrine hydrochloride

Downstream raw materials:

(2S,5S,6R)-2-Hydroxy-4,5-dimethyl-2,6-diphenyl-morpholin-3-one