N-[5-(5H-pyrrolo[2, 1-c][1, 4]benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl]-2-nitrobenzamide

Base Information

Chemical Name:N-[5-(5H-pyrrolo[2, 1-c][1, 4]benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl]-2-nitrobenzamide
CAS No.:200879-03-4
Molecular Formula:C₂₅H₁₉N₅O₄
Molecular Weight:453.457
Hs Code.:

Synonyms:N-[5-(5H-pyrrolo[2, 1-c][1, 4]benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl]-2-nitrobenzamide

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Chemical Property of N-[5-(5H-pyrrolo[2, 1-c][1, 4]benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl]-2-nitrobenzamide

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Technology Process of N-[5-(5H-pyrrolo[2, 1-c][1, 4]benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl]-2-nitrobenzamide

There total 8 articles about N-[5-(5H-pyrrolo[2, 1-c][1, 4]benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl]-2-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1003-29-8,254729-95-8
2-pyrrole aldehyde

: 200879-03-4
N-[5-(5H-pyrrolo[2, 1-c][1, 4]benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl]-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 0 °C

2: H₂ / Pd/C / ethanol / Ambient temperature

3: Et₃N / CH₂Cl₂ / Ambient temperature

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(99)00279-6

Reference yield:

: 22162-51-2
1-(2-Nitrobenzyl)-2-pyrrolecarboxaldehyde

: 200879-03-4
N-[5-(5H-pyrrolo[2, 1-c][1, 4]benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl]-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / Pd/C / ethanol / Ambient temperature

2: Et₃N / CH₂Cl₂ / Ambient temperature

With hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1016/S0960-894X(99)00279-6

Reference yield:

: 612-23-7
2-nitrobenzyl chloride

: 200879-03-4
N-[5-(5H-pyrrolo[2, 1-c][1, 4]benzodiazepin-10(11H)-ylcarbonyl)-2-pyridinyl]-2-nitrobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 0 °C

2: H₂ / Pd/C / ethanol / Ambient temperature

3: Et₃N / CH₂Cl₂ / Ambient temperature

With hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/S0960-894X(99)00279-6