5-difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Base Information

Chemical Name:5-difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine
CAS No.:1262859-91-5
Molecular Formula:C₁₃H₁₅F₃N₂O
Molecular Weight:272.27
Hs Code.:

Synonyms:5-difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

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Technology Process of 5-difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

There total 8 articles about 5-difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262859-90-4
5-Difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-morpholine-3-thione

: 1262859-91-5
5-difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: With ammonia; In methanol; at 70 - 80 ℃;

Reference yield:

: 1262859-83-5
2-(5-bromo-2-fluorophenyl)-2-(difluoromethyl)-1-(2-nitrophenylsulfonyl)aziridine

: 1262859-91-5
5-difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran

2: trifluoroacetic acid / dichloromethane; 4-methyl-morpholine

3: potassium carbonate / N,N-dimethyl-formamide

4: hydrogen; sodium acetate / Pd on charcoal / tetrahydrofuran; methanol

5: toluene; acetone

6: ammonia; methanol

With sodium hydride; hydrogen; sodium acetate; potassium carbonate; trifluoroacetic acid; Pd on charcoal; In tetrahydrofuran; 4-methyl-morpholine; methanol; dichloromethane; ammonia; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1262941-31-0
2-Amino-2-(5-bromo-2-fluoro-phenyl)-3,3-difluoro-propan-1-ol

: 1262859-91-5
5-difluoromethyl-5-(2-fluoro-phenyl)-2,2-dimethyl-5,6-dihydro-2H-[1,4]oxazin-3-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1: potassium hydrogencarbonate / acetonitrile, 2-nitrobenzenesulfonyl chloride

2: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran

3: trifluoroacetic acid / dichloromethane; 4-methyl-morpholine

4: potassium carbonate / N,N-dimethyl-formamide

5: hydrogen; sodium acetate / Pd on charcoal / tetrahydrofuran; methanol

6: toluene; acetone

7: ammonia; methanol

With sodium hydride; hydrogen; sodium acetate; potassium carbonate; potassium hydrogencarbonate; trifluoroacetic acid; Pd on charcoal; In tetrahydrofuran; 4-methyl-morpholine; methanol; dichloromethane; acetonitrile, 2-nitrobenzenesulfonyl chloride; ammonia; N,N-dimethyl-formamide; acetone; toluene;