(6S)-11-deazatetrahydrohomofolate

Base Information

Chemical Name:(6S)-11-deazatetrahydrohomofolate
CAS No.:119770-58-0
Molecular Formula:C₂₁H₂₆N₆O₆
Molecular Weight:458.474
Hs Code.:

Synonyms:(6S)-11-deazatetrahydrohomofolate

Suppliers and Price of (6S)-11-deazatetrahydrohomofolate

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Chemical Property of (6S)-11-deazatetrahydrohomofolate

Chemical Property:

Purity/Quality:

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Technology Process of (6S)-11-deazatetrahydrohomofolate

There total 12 articles about (6S)-11-deazatetrahydrohomofolate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 106918-32-5
4-carbomethoxyphenylacetaldehyde

: 119770-58-0
(6S)-11-deazatetrahydrohomofolate

Guidance literature:: Multi-step reaction with 9 steps

1: 54 percent / benzene / 40 h / Heating

2: H₂ / 5percent Pd/C / ethyl acetate / 18 h / 517.1 Torr

3: 92 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating

4: 80 percent / hydrazine / methanol / 48 h

5: 75 percent / methylmorpholine / methanol / 3 h / Heating

6: 1N HCl, TFA / 60 °C

8: 50 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide; dimethylsulfoxide / 18 h / solid phase coupling

9: 2-mercaptoethanol, glucose 6-phosphate / dimethylsulfoxide-d6 / 3 h / pH 5.5, Lactobacillus casei DHFR, NADPH

With 4-methyl-morpholine; 2-methylmorpholine; pyridine; hydrogenchloride; D-glucose 6-phosphate; hydroxylamine hydrochloride; hydrogen; trifluoroacetic acid; 2-hydroxyethanethiol; hydrazine; isobutyl chloroformate; palladium on activated charcoal; In methanol; dimethylsulfoxide-d6; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00126a022

Reference yield:

: 106918-31-4
1-methoxy-2-(4-carbomethoxyphenyl)ethylene

: 119770-58-0
(6S)-11-deazatetrahydrohomofolate

Guidance literature:: Multi-step reaction with 10 steps

1: 86 percent / H₂O, conc. H₂SO₄ / tetrahydrofuran / 11 h / Heating

2: 54 percent / benzene / 40 h / Heating

3: H₂ / 5percent Pd/C / ethyl acetate / 18 h / 517.1 Torr

4: 92 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating

5: 80 percent / hydrazine / methanol / 48 h

6: 75 percent / methylmorpholine / methanol / 3 h / Heating

7: 1N HCl, TFA / 60 °C

9: 50 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide; dimethylsulfoxide / 18 h / solid phase coupling

10: 2-mercaptoethanol, glucose 6-phosphate / dimethylsulfoxide-d6 / 3 h / pH 5.5, Lactobacillus casei DHFR, NADPH

With 4-methyl-morpholine; 2-methylmorpholine; pyridine; hydrogenchloride; D-glucose 6-phosphate; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; trifluoroacetic acid; 2-hydroxyethanethiol; hydrazine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; dimethylsulfoxide-d6; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00126a022

Reference yield:

: 1571-08-0
methyl 4-formylbenzoate

: 119770-58-0
(6S)-11-deazatetrahydrohomofolate

Guidance literature:: Multi-step reaction with 11 steps

1: 1.) NaOMe / 1.) MeOH, r.t., 30 min, 2.) C₆H₆, a) reflux, 3 h, b) r.t., 18 h

2: 86 percent / H₂O, conc. H₂SO₄ / tetrahydrofuran / 11 h / Heating

3: 54 percent / benzene / 40 h / Heating

4: H₂ / 5percent Pd/C / ethyl acetate / 18 h / 517.1 Torr

5: 92 percent / hydroxylamine hydrochloride, pyridine / methanol / 1 h / Heating

6: 80 percent / hydrazine / methanol / 48 h

7: 75 percent / methylmorpholine / methanol / 3 h / Heating

8: 1N HCl, TFA / 60 °C

10: 50 percent / N-methylmorpholine, isobutyl chloroformate / dimethylformamide; dimethylsulfoxide / 18 h / solid phase coupling

11: 2-mercaptoethanol, glucose 6-phosphate / dimethylsulfoxide-d6 / 3 h / pH 5.5, Lactobacillus casei DHFR, NADPH

With 4-methyl-morpholine; 2-methylmorpholine; pyridine; hydrogenchloride; D-glucose 6-phosphate; sulfuric acid; hydroxylamine hydrochloride; water; hydrogen; sodium methylate; trifluoroacetic acid; 2-hydroxyethanethiol; hydrazine; isobutyl chloroformate; palladium on activated charcoal; In tetrahydrofuran; methanol; dimethylsulfoxide-d6; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jm00126a022