4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)-3-nitrobenzonitrile

Base Information

Chemical Name:4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)-3-nitrobenzonitrile
CAS No.:1384542-85-1
Molecular Formula:C₂₅H₁₉N₇O₂
Molecular Weight:449.472
Hs Code.:

Synonyms:4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)-3-nitrobenzonitrile

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Chemical Property of 4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)-3-nitrobenzonitrile

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Technology Process of 4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)-3-nitrobenzonitrile

There total 5 articles about 4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)-3-nitrobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 939-80-0
4-chloro-3-nitrobenzonitrile

: 1384542-72-6
3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazole

: 1384542-85-1
4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)-3-nitrobenzonitrile

Guidance literature:: With caesium carbonate; In acetonitrile; at 70 ℃; for 4h;

Reference yield:

: (4-bromo-3-(isopropyl)-1-(4-methoxybenzyl)-1H-indazole)

: 1384542-85-1
4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)-3-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) oxide; caesium carbonate; 8-quinolinol / dimethyl sulfoxide / 125 °C

2: trifluoroacetic acid / 5 h / 100 °C

3: caesium carbonate / acetonitrile / 4 h / 70 °C

With copper(I) oxide; 8-quinolinol; caesium carbonate; trifluoroacetic acid; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 1073-06-9
3-fluorobromobenzene

: 1384542-85-1
4-(3-isopropyl-4-(4-(pyridin-3-yl)-1H-imidazol-1-yl)-1H-indazol-1-yl)-3-nitrobenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 0.25 h / Inert atmosphere

1.3: 0 - 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere

3.1: copper(I) oxide; caesium carbonate; 8-quinolinol / dimethyl sulfoxide / 125 °C

4.1: trifluoroacetic acid / 5 h / 100 °C

5.1: caesium carbonate / acetonitrile / 4 h / 70 °C

With copper(I) oxide; 8-quinolinol; n-butyllithium; sodium hydride; caesium carbonate; diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;