methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate

Base Information

Chemical Name:methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate
CAS No.:1417885-97-2
Molecular Formula:C₁₈H₁₄F₃N₃O₃
Molecular Weight:377.323
Hs Code.:

Synonyms:methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate

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Chemical Property of methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate

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Technology Process of methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate

There total 2 articles about methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 525362-07-6
methyl 2-methyl-4-(4,4,5 ,5-tetramethyl-1,3 ,2-dioxaborolan-2-yl)benzoate

: 1417885-96-1
3-bromo-1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole

: 1417885-97-2
methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; In 1,4-dioxane; water; at 140 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 103962-05-6
1-iodo-4-(trifluoromethoxy)benzene

: 1417885-97-2
methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; caesium carbonate / dimethyl sulfoxide / 20 h / 100 °C / Inert atmosphere

2: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 0.5 h / 140 °C / Microwave irradiation

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate; caesium carbonate; In 1,4-dioxane; water; dimethyl sulfoxide;

Reference yield: 95.0%

: 1417885-97-2
methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate

: 1417885-98-3
2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoic acid

Guidance literature:: methyl 2-methyl-4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)benzoate; With sodium hydroxide; In tetrahydrofuran; methanol;

With hydrogenchloride; In tetrahydrofuran; water;