(R)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

Base Information

Chemical Name:(R)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate
CAS No.:1416956-16-5
Molecular Formula:C₃₃H₃₉F₂N₉O₄
Molecular Weight:663.727
Hs Code.:

Synonyms:(R)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

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Chemical Property of (R)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

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Technology Process of (R)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

There total 6 articles about (R)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-(piperazin-1-yl)-1,3,5-triazin-2-yl)morpholine

: 18942-49-9
Boc-D-Phe-OH

: 1416956-16-5
(R)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/ml300336j

Reference yield:

: 705-09-9
2-(difluoromethyl)-1H-benzo[d]imidazole

: 1416956-16-5
(R)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 140 °C / Sealed tube; Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml300336j

Reference yield:

: 1345988-67-1
4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholinyl-1,3,5-triazin-2-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1416956-16-5
(R)-tert-butyl (1-(4-(4-(2-(difluoromethyl)-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)-1-oxo-3-phenylpropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 0.33 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ml300336j