N-ETHOXYCARBONYL-L-PHENYLALANINE

Base Information

• Chemical Name: N-ETHOXYCARBONYL-L-PHENYLALANINE
• CAS No.: 19887-32-2
• Molecular Formula: C12H15 N O4
• Molecular Weight: 237.255
• Mol file: 19887-32-2.mol

Synonyms:Alanine,N-carboxy-3-phenyl-, N-ethyl ester (7CI); Alanine, N-carboxy-3-phenyl-, N-ethylester, L- (8CI); N-(Ethoxycarbonyl)-L-phenylalanine;N-(Ethoxycarbonyl)phenylalanine

Chemical Property of N-ETHOXYCARBONYL-L-PHENYLALANINE

Chemical Property:

• Vapor Pressure: 9.06E-08mmHg at 25°C
• Melting Point: 78-82 °C(lit.)
• Refractive Index: 1.538
• Boiling Point: 419oC at 760 mmHg
• PKA: 3.56±0.10(Predicted)
• Flash Point: 207.2oC
• PSA: 75.63000
• Density: 1.213g/cm3
• LogP: 1.81930
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98.5% ^*data from raw suppliers

N-Ethoxycarbonyl-L-phenylalanine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ETHOXYCARBONYL-L-PHENYLALANINE

There total 7 articles about N-ETHOXYCARBONYL-L-PHENYLALANINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + chloroformic acid ethyl ester (541-41-3) → (ethoxycarbonyl)-L-phenylalanine (19887-32-2)

Guidance literature:

With sodium hydroxide; sodium carbonate; In water; at 0 - 20 ℃; for 1h;

DOI:10.1016/S0957-4166(02)00183-0

Reference yield: 85.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + ethyl α-methoxyvinyl carbonate (74877-64-8) → (ethoxycarbonyl)-L-phenylalanine (19887-32-2)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jo01310a057

Reference yield: 70.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + chloroformic acid ethyl ester (541-41-3) → 2-Ethoxycarbonylamino-3-phenyl-propionic acid (19887-32-2)

Guidance literature:

DOI:10.1021/jo00012a019

upstream raw materials:

L-phenylalanine

ethyl α-methoxyvinyl carbonate

chloroformic acid ethyl ester

N-(Ethyloxycarbonyl)-L-Phe-p-nitrophenyl ester

Downstream raw materials:

2(S)-N-(ethyloxycarbonyl)-N'-methoxy-N'-methylphenylalaninamide

S₂-L-Phe-L-His-OMe

4-benzyl-5-oxo-oxazolidine-3-carboxylic acid ethyl ester

cis-N-(1-butyl-2,3-dihydro-1H-inden-2-yl)-4-methylbenzenesulfonamide