3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochlroide

Base Information

Chemical Name:3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochlroide
CAS No.:1366348-84-6
Molecular Formula:C₂₂H₂₅ClFNO₂*ClH
Molecular Weight:426.358
Hs Code.:

Synonyms:3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochlroide

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Chemical Property of 3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochlroide

Chemical Property:

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Technology Process of 3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochlroide

There total 4 articles about 3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochlroide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1366349-33-8
3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol

: 1366348-84-6
3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochlroide

Guidance literature:: With hydrogenchloride;
DOI:10.1016/j.bmc.2012.01.022

Reference yield:

: 104413-57-2
3-(4-fluorophenoxy)-1-propanol

: 1366348-84-6
3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochlroide

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 12 h / 20 °C

2: potassium carbonate; potassium iodide / 1,2-dimethoxyethane / 16 h / Reflux; Inert atmosphere

3: hydrogenchloride

With hydrogenchloride; potassium carbonate; triethylamine; potassium iodide; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/j.bmc.2012.01.022

Reference yield:

: 371-41-5
4-Fluorophenol

: 1366348-84-6
3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol hydrochlroide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate; potassium iodide / isopropyl alcohol / 12 h / 80 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 20 °C

3: potassium carbonate; potassium iodide / 1,2-dimethoxyethane / 16 h / Reflux; Inert atmosphere

4: hydrogenchloride

With hydrogenchloride; potassium carbonate; triethylamine; potassium iodide; In 1,2-dimethoxyethane; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.01.022