3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol

Base Information

Chemical Name:3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol
CAS No.:1366349-33-8
Molecular Formula:C₂₂H₂₅ClFNO₂
Molecular Weight:389.897
Hs Code.:

Synonyms:3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol

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Chemical Property of 3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol

Chemical Property:

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Technology Process of 3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol

There total 3 articles about 3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(4-fluorophenoxy)propyl methanesulfonate

: 3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octan-3-ol

: 1366349-33-8
3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol

Guidance literature:: With potassium carbonate; potassium iodide; In 1,2-dimethoxyethane; for 16h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmc.2012.01.022

Reference yield:

: 104413-57-2
3-(4-fluorophenoxy)-1-propanol

: 1366349-33-8
3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 12 h / 20 °C

2: potassium carbonate; potassium iodide / 1,2-dimethoxyethane / 16 h / Reflux; Inert atmosphere

With potassium carbonate; triethylamine; potassium iodide; In 1,2-dimethoxyethane; dichloromethane;
DOI:10.1016/j.bmc.2012.01.022

Reference yield:

: 371-41-5
4-Fluorophenol

: 1366349-33-8
3-(4-chlorophenyl)-8-(3-(4-fluorophenoxy)propyl)-8-azabicyclo[3.2.1]octan-3-ol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; potassium iodide / isopropyl alcohol / 12 h / 80 °C / Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 20 °C

3: potassium carbonate; potassium iodide / 1,2-dimethoxyethane / 16 h / Reflux; Inert atmosphere

With potassium carbonate; triethylamine; potassium iodide; In 1,2-dimethoxyethane; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.bmc.2012.01.022