(9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Base Information

Chemical Name:(9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone
CAS No.:1263265-20-8
Molecular Formula:C₃₀H₄₆FN₃O₃SSi
Molecular Weight:575.863
Hs Code.:

Synonyms:(9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

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Chemical Property of (9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

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Technology Process of (9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

There total 7 articles about (9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1179338-35-2
3-(2-(tert-Butyldimethylsilyloxy)ethyl)-2-fluorobenzaldehyde

: 1179336-73-2
(2-isopropylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate

: 1263265-20-8
(9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Guidance literature:: 3-(2-(tert-Butyldimethylsilyloxy)ethyl)-2-fluorobenzaldehyde; (2-isopropylthiazol-4-yl)(1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)methanone trifluoroacetate; acetic acid; In 1-methyl-pyrrolidin-2-one; for 0.5h;

With sodium tris(acetoxy)borohydride; In 1-methyl-pyrrolidin-2-one;

With sodium hydrogencarbonate; In 1-methyl-pyrrolidin-2-one; water; pH=8;

Reference yield:

: 50919-06-7
2-(2-fluorophenyl)ethanol

: 1263265-20-8
(9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 3.5 h / 20 °C / Cooling with ice

2.1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium / tetrahydrofuran / 2.58 h / -78 °C

2.2: 1.17 h / -78 - 20 °C

3.1: acetic acid / 1-methyl-pyrrolidin-2-one / 0.5 h

3.3: pH 8

With 2,2,6,6-tetramethyl-piperidine; 1H-imidazole; n-butyllithium; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;

Reference yield:

: 300831-06-5
4-isopropylthiazole-2-carboxylic acid

: 1263265-20-8
(9-(3-(2-(tert-butyldimethylsilyloxy)ethyl)-2-fluorobenzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane; tetrahydrofuran / 4.83 h / Inert atmosphere

2.1: dichloromethane / 0.5 h / 20 °C

3.1: acetic acid / 1-methyl-pyrrolidin-2-one / 0.5 h

3.3: pH 8

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; acetic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane;