Technology Process of N-(3'-(4-methoxybenzyloxy)-5'-(pyridin-3-ylamino)biphenyl-3-yl)acetamide
There total 5 articles about N-(3'-(4-methoxybenzyloxy)-5'-(pyridin-3-ylamino)biphenyl-3-yl)acetamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3-bromo-5-triisopropylsilanyloxy-phenyl)-pyridin-3-yl-amine;
With
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; ethanol;
at 20 ℃;
for 0.166667h;
Inert atmosphere;
3-Acetamidophenylboronic acid;
With
sodium carbonate;
In
1,2-dimethoxyethane; ethanol; water;
at 85 ℃;
Inert atmosphere;
DOI:10.1021/jm100659v
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 90 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; ethanol / 0.17 h / 20 °C / Inert atmosphere
2.2: 85 °C / Inert atmosphere
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tetrakis(triphenylphosphine) palladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate;
In
1,2-dimethoxyethane; ethanol; toluene;
1.1: Buchwald-Hartwig amination / 2.1: Suzuki coupling / 2.2: Suzuki coupling;
DOI:10.1021/jm100659v
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: tetrabutylammomium bromide; oxygen; potassium hydroxide / tetramethylurea / 20 °C
2.1: tetrabutylammomium bromide; hydrogen bromide / 72 h / Reflux
3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
3.2: 20 h / 0 - 20 °C / Inert atmosphere
4.1: tris(dibenzylideneacetone)dipalladium(0) chloroform complex; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate / toluene / 90 °C / Inert atmosphere
5.1: tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; ethanol / 0.17 h / 20 °C / Inert atmosphere
5.2: 85 °C / Inert atmosphere
With
tris(dibenzylideneacetone)dipalladium(0) chloroform complex; tetrakis(triphenylphosphine) palladium(0); tetrabutylammomium bromide; hydrogen bromide; oxygen; sodium hydride; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; potassium hydroxide; sodium t-butanolate;
In
1,2-dimethoxyethane; ethanol; N,N-dimethyl-formamide; toluene; tetramethylurea; mineral oil;
4.1: Buchwald-Hartwig amination / 5.1: Suzuki coupling / 5.2: Suzuki coupling;
DOI:10.1021/jm100659v
