(4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-trien-21-ol

Base Information

• Chemical Name: (4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-trien-21-ol
• CAS No.: 189451-74-9
• Molecular Formula: C₂₈H₃₁BrO₆
• Molecular Weight: 543.455

Synonyms:(4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-trien-21-ol

Chemical Property of (4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-trien-21-ol

Chemical Property:

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Technology Process of (4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-trien-21-ol

There total 4 articles about (4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-trien-21-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-triene (189451-78-3) → (4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-trien-21-ol (189451-74-9)

Guidance literature:

With sodium hydride; ethanethiol; In N,N-dimethyl-formamide; at 100 ℃; for 3h;

DOI:10.1016/S0957-4166(97)00047-5

Reference yield:

5-bromo-1,3-bis(bromomethyl)-2-methoxybenzene (118249-11-9) → (4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-trien-21-ol (189451-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / NaH, KBF₄ / tetrahydrofuran / 22 h / Heating

2: 96 percent / ethanethiol, NaH / dimethylformamide / 3 h / 100 °C

With sodium hydride; potassium tetrafluoroborate; ethanethiol; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(97)00047-5

Reference yield:

(S,S)-(+)-1,11-diphenyl-3,6,9-trioxaundecane-1,11-diol (93417-23-3) → (4S,14S)-19-Bromo-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1(20),17(21),18-trien-21-ol (189451-74-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / NaH, KBF₄ / tetrahydrofuran / 22 h / Heating

2: 96 percent / ethanethiol, NaH / dimethylformamide / 3 h / 100 °C

With sodium hydride; potassium tetrafluoroborate; ethanethiol; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/S0957-4166(97)00047-5

upstream raw materials:

(4S,14S)-19-Bromo-21-methoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

5-bromo-1,3-bis(bromomethyl)-2-methoxybenzene

(S,S)-(+)-1,11-diphenyl-3,6,9-trioxaundecane-1,11-diol

Downstream raw materials:

(4S,14S)-19-Bromo-21-methoxymethoxy-4,14-diphenyl-3,6,9,12,15-pentaoxa-bicyclo[15.3.1]henicosa-1⁽²⁰⁾,17⁽²¹⁾,18-triene

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