Ethyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester

Base Information

Chemical Name:Ethyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester
CAS No.:131631-96-4
Molecular Formula:C₃₂H₃₅N₃O₅
Molecular Weight:541.647
Hs Code.:

Synonyms:Ethyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester

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Chemical Property of Ethyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester

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Technology Process of Ethyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester

There total 4 articles about Ethyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 33844-21-2
2-nitro-4-methoxybenzoic acid

: 131631-96-4
Ethyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / 2 h / Heating

2: Et₃N / dimethylformamide / 2 h / 0 - 5 °C

3: 79 percent / H₂ / 5percent Pd/C / ethanol

4: 93 percent / aq. NaHCO₃ / CH₂Cl₂

5: 1.) NaH / 1.) DMF, from 45 to 50 deg C, 30 min, 2.) DMF, RT, 1 h

With thionyl chloride; hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.725

Reference yield:

: 50424-96-9
4-methoxy-2-nitro-benzoyl chloride

: 131631-96-4
Ethyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / dimethylformamide / 2 h / 0 - 5 °C

2: 79 percent / H₂ / 5percent Pd/C / ethanol

3: 93 percent / aq. NaHCO₃ / CH₂Cl₂

4: 1.) NaH / 1.) DMF, from 45 to 50 deg C, 30 min, 2.) DMF, RT, 1 h

With hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.725

Reference yield:

: 131632-13-8
1-[1-(4-Methoxy-2-nitro-benzoyl)-piperidin-4-yl]-3,4-dihydro-1H-quinolin-2-one

: 131631-96-4
Ethyl-{5-methoxy-2-[4-(2-oxo-3,4-dihydro-2H-quinolin-1-yl)-piperidine-1-carbonyl]-phenyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / H₂ / 5percent Pd/C / ethanol

2: 93 percent / aq. NaHCO₃ / CH₂Cl₂

3: 1.) NaH / 1.) DMF, from 45 to 50 deg C, 30 min, 2.) DMF, RT, 1 h

With hydrogen; sodium hydride; sodium hydrogencarbonate; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1248/cpb.44.725