6-Ethyl-5-(3-nitro-4-piperazin-1-yl-phenyl)-pyrimidine-2,4-diamine

Base Information

• Chemical Name: 6-Ethyl-5-(3-nitro-4-piperazin-1-yl-phenyl)-pyrimidine-2,4-diamine
• CAS No.: 123240-22-2
• Molecular Formula: C₁₆H₂₁N₇O₂
• Molecular Weight: 343.388
• Mol file: 123240-22-2.mol

Synonyms:6-Ethyl-5-(3-nitro-4-piperazin-1-yl-phenyl)-pyrimidine-2,4-diamine

Chemical Property of 6-Ethyl-5-(3-nitro-4-piperazin-1-yl-phenyl)-pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Ethyl-5-(3-nitro-4-piperazin-1-yl-phenyl)-pyrimidine-2,4-diamine

There total 1 articles about 6-Ethyl-5-(3-nitro-4-piperazin-1-yl-phenyl)-pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

piperazine (110-85-0) + 2,4-diamino-5-(4-chloro-3-nitrophenyl)-6-ethylpyrimidine (21813-35-4) → 6-Ethyl-5-(3-nitro-4-piperazin-1-yl-phenyl)-pyrimidine-2,4-diamine (123240-22-2)

Guidance literature:

for 6h; Heating;

DOI:10.1021/jm00131a009

Reference yield: 88.0%

6-Ethyl-5-(3-nitro-4-piperazin-1-yl-phenyl)-pyrimidine-2,4-diamine (123240-22-2) → 5-(3-Amino-4-piperazin-1-yl-phenyl)-6-ethyl-pyrimidine-2,4-diamine (123240-37-9)

Guidance literature:

With tin(ll) chloride; In ethanol; for 3h; Heating;

DOI:10.1021/jm00131a009

Reference yield:

6-Ethyl-5-(3-nitro-4-piperazin-1-yl-phenyl)-pyrimidine-2,4-diamine (123240-22-2) → 2,4-diamino-6-ethyl-5-(4-piperazin-1-ylphenyl)pyrimidine

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / SnCl₂*2H₂O / ethanol / 3 h / Heating

2: 1.) NaNO₂, 5 M hydrochloric acid, 2.) NaN₃ / 1.) H₂O, 0 deg C, 2.) 0 deg C, 2 h

3: 64 percent / N₂H₄*H₂O / 0.5 h / Heating

With hydrogenchloride; sodium azide; hydrazine hydrate; tin(ll) chloride; sodium nitrite; In ethanol;

DOI:10.1021/jm00131a009

upstream raw materials:

piperazine

2,4-diamino-5-(4-chloro-3-nitrophenyl)-6-ethylpyrimidine

Downstream raw materials:

5-(3-Amino-4-piperazin-1-yl-phenyl)-6-ethyl-pyrimidine-2,4-diamine

5-(3-Azido-4-piperazin-1-yl-phenyl)-6-ethyl-pyrimidine-2,4-diamine