21813-35-4

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine is used as a potential pharmaceutical agent for its structural features and chemical properties. 2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine's amino, chloro, nitro, and ethyl groups may contribute to its interaction with biological targets, such as enzymes or receptors, which could be harnessed for therapeutic purposes.
Used in Chemical Research:
In the field of chemical research, 2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine serves as a subject of study for understanding the effects of its molecular structure on its reactivity and potential applications. Researchers may investigate its synthesis, stability, and interactions with other molecules to uncover new insights into its chemical behavior.
Used in Material Science:
2,4-Diamino-5-(3-amino-4-chloro-5-nitrophenyl)-6-ethylpyrimidine may also find applications in material science, where its unique structure could be utilized to develop new materials with specific properties. For instance, its amino and chloro groups could be involved in the formation of coordination complexes or contribute to the creation of novel polymers with tailored characteristics.

InChI:InChI=1/C12H12ClN5O2/c1-2-8-10(11(14)17-12(15)16-8)6-3-4-7(13)9(5-6)18(19)20/h3-5H,2H2,1H3,(H4,14,15,16,17)

Upstream product

• 1336-21-6 ammonium hydroxide 
• 58-14-0 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidine 
• 160428-27-3 2,4-diamino-5-(4-chlorophenyl)-6-<<1-(2,3,5,6-tetrafluoro-4-trifluoromethyl)phenoxy>ethyl>pyrimidine 
• 24851-19-2 2,4-diamino-5-(3-amino-4-chlorophenyl)-6-ethylpyrimidine 
• 143947-35-7 2,4-Diacetamido-5-(4-chloro-3-nitrophenyl)-6-ethylpyrimidine 
• 59193-98-5 2,4-diamino-5-(4-chlorophenyl)-6-(1-hydroxyethyl)pyrimidine 
• 160428-28-4 2,4-diamino-5-(4-chloro-3-nitrophenyl)-6-<<1-(2,3,5,6-tetrafluoro-4-trifluoromethyl)phenoxy>ethyl>pyrimidine 

Downstream Products

• 123240-27-7 NSC 372939 
• 95458-54-1 2,4-diamino-6-ethyl-5-(4-methoxy-3-nitrophenyl)pyrimidine 
• 123240-23-3 6-Ethyl-5-[4-(4-methyl-piperazin-1-yl)-3-nitro-phenyl]-pyrimidine-2,4-diamine 
• 123240-24-4 6-Ethyl-5-(4-morpholin-4-yl-3-nitro-phenyl)-pyrimidine-2,4-diamine 
• 104484-42-6 2,4-diamino-6-ethyl-5-(3-nitro-4-piperidinophenyl)pyrimidine 
• 104498-93-3 4-Amino-6-ethyl-5-(3-nitro-4-piperidin-1-yl-phenyl)-1H-pyrimidin-2-one 
• 104498-90-0 2-amino-6-ethyl-5-(3-nitro-4-piperidinophenyl)pyrimidin-4(3H)-one 
• 104498-96-6 4-Amino-5-(3-amino-4-chloro-phenyl)-6-ethyl-1H-pyrimidin-2-one 
• 104498-95-5 2-Amino-5-(3-amino-4-chloro-phenyl)-6-ethyl-3H-pyrimidin-4-one 
• 113512-77-9 2,4-diamino-5-(5-amino-4-chloro-2-trifluoromethylsulphonyloxy)-6-ethylpyrimidine 
• 95458-58-5 2,4-diamino-5-(4-azido-3-ethoxyphenyl)-6-ethylpyrimidine 
• 95458-55-2 2,4-diamino-5-(4-azido-3-methoxyphenyl)-6-ethylpyrimidine 
• 95458-40-5 2,4-diamino-5-(3-azido-4-chlorophenyl)-6-ethylpyrimidine 
• 95458-43-8 2,4-diamino-5-(3-azido-4-chlorophenyl)-6-ethylpyrimidine ethanesulphonic acid salt 

Relevant academic research and scientific papers

Triazenyl-substituted phenyl pyrimidines and their use in therapy

Compounds of formula I: STR1 wherein R1, R2, R3 and R4 are each independently hydrogen, alkyl or acyl, R5 is alkyl, X represents a hydrophobic substituent and n is an integer from 1 to 3, and R6

Insecticidal 5-substituted-2,4-diaminopyrimidine derivatives

An insecticidal composition comprising, in admixture with an agriculturally acceptable carrier, an insecticidally effective amount of a compound of the formula: STR1 wherein R, R1, R2, R3, R7, R8, m, n, and p are as defined herein, and agriculturally acceptable salts thereof, and methods of using the same.

Structural Studies on Bio-active Compounds. Part 25. Synthesis and Properties of Potential Metabolites of the Diaminopyrimidine Antifolate 2,4-Diamino-5-(3-azido-4-chlorophenyl)-6-ethylpyrimidine (MZPES)

A series of potential metabolites of the antitumor diaminopyrimidine m-azidopyrimethamine (2, MZP) has been prepared.Selective reduction of the nitro substituent of the nitropyrimidine 3-oxide8, prepared by performic acid oxidation and diazotisation-azida

Regioselective Deacylation of 2,4-Diacylaminopyrimidine Derivatives by Lewis Acids and Crystal Structures of Two Products

Deacylation of 2,4-diacylamino derivatives of pyrimethamine and related diaminopyrimidines with tin(II) chloride or zinc chloride, in ethanol or propan-2-ol, affords 2-acyl-4-aminopyrimidines exclusively.Regioselective 4-deacylation was observed by 1H NMR spectroscopy and established by crystallographic analysis of the 2,4-dipropionylpyrimidine 11 and the corresponding 4-amino-2-propionylpyrimidine deacylation product 17.The latter exists in the solid state as an unusual base-pair dimer linked by two pairs of equivalent hydrogen bonds.

Stuctural Studies on Bio-active Compounds. Part 5. Synthesis and Properties of 2,4-Diaminopyrimidine Dihydrofolate Reductase Inhibitors bearing Lipophilic Azido Groups

A series of 2,4-diamino-5-(azidoaryl)-6-alkylpyrimidines has been prepared.The azide (36) (MZP) can be reduced by thiol reagents to the corresponding amine (28) but reductive deazidation occured when the series of azidophenyl derivatives was heated with hydrazine hydrate.Degradation of azide (36) in a trifluoroacetic acid-trifluoromethanesulphonic acid mixture at 0 deg C affords a means of introducing the bulky trifluoromethylsulphonyloxy substituent into the hindered ortho-position of the 5-aryl substituent.The products formed from thermolysis and photolysis of the azide (36) and the planar analogue 2,4-diamino-6-azidoquinazoline (70) derive from the triplet nitrene reactive intermediates. The azido compounds are potent inhibitors of rat liver dihydrofolate reductase although not as active as metoprin.The azide (36), as its ethanesulphonic acid salt, was selected for clinical trial on the basis of its ease of synthesis and suitable biological and pharmaceutical properties, and has a shorter biological half-life than compounds of comparable hydrophobicity.

Structural Studies on Bio-active Compounds. Part 3. Re-examination of the Hydrolysis of the Antimalarial Drug Pyrimethamine and Related Derivatives and Crystal Structure of a Hydrolysis Product

Hydrolysis of the diaminopyrimidine pyrimethamine and some of its 5-(3'-substituted)phenyl derivatives with 6M-hydrochloric acid or deamination with nitrous acid, affords mixtures of isomeric aminopyrimidinones.The ratio of products is influenced by the n