3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propan-1-ol

Base Information

• Chemical Name: 3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propan-1-ol
• CAS No.: 1617532-01-0
• Molecular Formula: C₁₇H₁₈N₂O₃S
• Molecular Weight: 330.408
• Mol file: 1617532-01-0.mol

Synonyms:3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propan-1-ol

Chemical Property of 3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propan-1-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propan-1-ol

There total 1 articles about 3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

2-(3-hydroxypropyl)benzimidazole (2403-66-9) + toluene-4-sulfonic acid (104-15-4) → 3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propan-1-ol (1617532-01-0)

Guidance literature:

With dmap; triethylamine; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1039/c4ob00504j

Reference yield: 75.0%

3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propan-1-ol (1617532-01-0) → 3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propanal (1617531-85-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; for 2h; Inert atmosphere;

DOI:10.1039/c4ob00504j

Reference yield:

3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propan-1-ol (1617532-01-0) → (±)-(3S,4S)-3-(2-((3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propyl)(cyclopropyl)amino)ethyl)-7-fluoro-4-isopropylchroman-3-ol

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodane / dichloromethane / 2 h / Inert atmosphere

2: acetic acid; sodium cyanoborohydride / methanol / 17.5 h / 20 °C / Inert atmosphere

With sodium cyanoborohydride; Dess-Martin periodane; acetic acid; In methanol; dichloromethane;

DOI:10.1039/c4ob00504j

upstream raw materials:

2-(3-hydroxypropyl)benzimidazole

toluene-4-sulfonic acid

Downstream raw materials:

3-(1-p-toluenesulfonyl-1H-benzo[d]imidazol-2-yl)propanal