methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate

Base Information

• Chemical Name: methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate
• CAS No.: 1585969-87-4
• Molecular Formula: C₂₁H₁₆BrNO₃
• Molecular Weight: 410.267
• Mol file: 1585969-87-4.mol

Synonyms:methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate

Chemical Property of methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate

There total 2 articles about methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-bromo-5-methoxycarbonylaniline (46064-79-3) + 4-biphenyl-carboxylic acid chloride (14002-51-8) → methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate (1585969-87-4)

Guidance literature:

With dmap; at 20 ℃; for 18h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.02.014

Reference yield:

3-amino-4-bromobenzoic acid (2840-29-1) → methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate (1585969-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 24 h / 0 °C / Reflux

2: dmap / 18 h / 20 °C / Inert atmosphere

With dmap; thionyl chloride;

DOI:10.1016/j.ejmech.2014.02.014

Reference yield: 89.0%

methyl 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoate (1585969-87-4) → 3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoic acid (1585969-79-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 18h;

DOI:10.1016/j.ejmech.2014.02.014

upstream raw materials:

3-amino-4-bromobenzoic acid

2-bromo-5-methoxycarbonylaniline

4-biphenyl-carboxylic acid chloride

Downstream raw materials:

3-([1,1'-biphenyl]-4-ylcarboxamido)-4-bromobenzoic acid