(S)-2-amino-N^α-(tert-butyloxycarbonyl)-6-(4',5'-dimethyl-2'-nitroanilin-N-yl)hexanoic acid

Base Information

• Chemical Name: (S)-2-amino-N^α-(tert-butyloxycarbonyl)-6-(4',5'-dimethyl-2'-nitroanilin-N-yl)hexanoic acid
• CAS No.: 195812-20-5
• Molecular Formula: C₁₉H₂₉N₃O₆
• Molecular Weight: 395.456

Synonyms:(S)-2-amino-N^α-(tert-butyloxycarbonyl)-6-(4',5'-dimethyl-2'-nitroanilin-N-yl)hexanoic acid

Chemical Property of (S)-2-amino-N^α-(tert-butyloxycarbonyl)-6-(4',5'-dimethyl-2'-nitroanilin-N-yl)hexanoic acid

Chemical Property:

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Technology Process of (S)-2-amino-N^α-(tert-butyloxycarbonyl)-6-(4',5'-dimethyl-2'-nitroanilin-N-yl)hexanoic acid

There total 3 articles about (S)-2-amino-N^α-(tert-butyloxycarbonyl)-6-(4',5'-dimethyl-2'-nitroanilin-N-yl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4,5-dimethyl-1,2-dinitrobenzene (610-23-1) + Boc-Lys-OH (13734-28-6) → (S)-2-amino-Nα-(tert-butyloxycarbonyl)-6-(4',5'-dimethyl-2'-nitroanilin-N-yl)hexanoic acid (195812-20-5)

Guidance literature:

In pyridine; for 72h; Heating;

DOI:10.1021/jo980643l

Reference yield:

4,5-dimethyl-2-nitrobenzenamine (6972-71-0) → (S)-2-amino-Nα-(tert-butyloxycarbonyl)-6-(4',5'-dimethyl-2'-nitroanilin-N-yl)hexanoic acid (195812-20-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 41 g / potassium persulfate, conc.H₂SO₄ / H₂O / Ambient temperature

2: 50 percent / HNO₃, H₂O₂ / acetic acid / 2 h / 100 °C

3: 74 percent / pyridine / 72 h / Heating

With potassium peroxomonosulphate; sulfuric acid; dihydrogen peroxide; nitric acid; In pyridine; water; acetic acid;

DOI:10.1021/jo980643l

Reference yield:

1,2-Dimethyl-4-nitro-5-nitroso-benzene (408328-24-5) → (S)-2-amino-Nα-(tert-butyloxycarbonyl)-6-(4',5'-dimethyl-2'-nitroanilin-N-yl)hexanoic acid (195812-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / HNO₃, H₂O₂ / acetic acid / 2 h / 100 °C

2: 74 percent / pyridine / 72 h / Heating

With dihydrogen peroxide; nitric acid; In pyridine; acetic acid;

DOI:10.1021/jo980643l

upstream raw materials:

4,5-dimethyl-1,2-dinitrobenzene

Boc-Lys-OH

4,5-dimethyl-2-nitrobenzenamine

1,2-Dimethyl-4-nitro-5-nitroso-benzene

Downstream raw materials:

(S)-6-(2-Amino-4,5-dimethyl-phenylamino)-2-tert-butoxycarbonylamino-hexanoic acid

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