(R)-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-2-methyl-4-(3-oxo-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

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Chemical Name:(R)-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-2-methyl-4-(3-oxo-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one
CAS No.:1290050-11-1
Molecular Formula:C₂₃H₃₀ClN₃O₃
Molecular Weight:431.963
Hs Code.:

Synonyms:(R)-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-2-methyl-4-(3-oxo-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

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Chemical Property of (R)-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-2-methyl-4-(3-oxo-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

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Technology Process of (R)-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-2-methyl-4-(3-oxo-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

There total 5 articles about (R)-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-2-methyl-4-(3-oxo-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 1290048-18-8
3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid

: 1290050-11-1
(R)-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-2-methyl-4-(3-oxo-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

Guidance literature:: 3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid; With triethylamine; HATU; In N,N-dimethyl-formamide; for 0.166667h;

piperidine; In N,N-dimethyl-formamide;

Reference yield:

: 1290048-20-2
{(R)-2-[tert-Butoxycarbonyl-(3-hydroxy-propyl)-amino]-1-methyl-ethyl}-carbamic acid benzyl ester

: 1290050-11-1
(R)-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-2-methyl-4-(3-oxo-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 760.05 Torr

1.2: 16 h

1.3: -15 - 0 °C

2.1: hydrogenchloride / methanol / 4 h

2.2: 16 h

2.3: 1 h

3.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium hypochlorite; potassium bromide / dichloromethane / 0 °C

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.17 h

With hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; hydrogen; sodium hydrogencarbonate; triethylamine; HATU; potassium bromide; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 39096-24-7,13565-06-5
3-chlorocinnamoyl chloride

: 1290050-11-1
(R)-1-[(E)-3-(3-chloro-phenyl)-acryloyl]-2-methyl-4-(3-oxo-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

1.2: 16 h

1.3: 0.25 h / 0 °C

2.1: hydrogenchloride / methanol / 2 h

2.2: 1,5,7-triazabucyclodec-5-ene / 16 h

2.3: 1 h

3.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane / 0.08 h / Cooling with ice

4.1: triethylamine; HATU / N,N-dimethyl-formamide / 0.17 h

With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydrogen; sodium hydrogencarbonate; triethylamine; HATU; potassium bromide; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;