3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid

Base Information

Chemical Name:3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid
CAS No.:1290048-18-8
Molecular Formula:C₁₈H₂₁ClN₂O₄
Molecular Weight:364.829
Hs Code.:

Synonyms:3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid

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Chemical Property of 3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid

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Technology Process of 3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid

There total 3 articles about 3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290048-20-2
{(R)-2-[tert-Butoxycarbonyl-(3-hydroxy-propyl)-amino]-1-methyl-ethyl}-carbamic acid benzyl ester

: 1290048-18-8
3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 760.05 Torr

1.2: 16 h

1.3: -15 - 0 °C

2.1: hydrogenchloride / methanol / 4 h

2.2: 16 h

2.3: 1 h

3.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium hypochlorite; potassium bromide / dichloromethane / 0 °C

With hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; hydrogen; sodium hydrogencarbonate; potassium bromide; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 39096-24-7,13565-06-5
3-chlorocinnamoyl chloride

: 1290048-18-8
3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h

1.2: 16 h

1.3: 0.25 h / 0 °C

2.1: hydrogenchloride / methanol / 2 h

2.2: 1,5,7-triazabucyclodec-5-ene / 16 h

2.3: 1 h

3.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate; potassium bromide / dichloromethane / 0.08 h / Cooling with ice

With hydrogenchloride; sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; hydrogen; sodium hydrogencarbonate; potassium bromide; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 1290048-21-3
3-{{(R)-2-[tert-butoxycarbonyl-(3-hydroxy-propyl)-amino]-1-methyl-ethyl}-[(E)-3-(3-chloro-phenyl)-acryloyl]-amino}-propionic acid methyl ester

: 1290048-18-8
3-{(R)-4-[(E)-3-(3-chloro-phenyl)-acryloyl]-3-methyl-7-oxo-[1,4]diazepan-1-yl}-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / methanol / 4 h

1.2: 16 h

1.3: 1 h

2.1: 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hydrogencarbonate; sodium hypochlorite; potassium bromide / dichloromethane / 0 °C

With hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium hydrogencarbonate; potassium bromide; In methanol; dichloromethane;