12a-N-((4-methoxyphenyl)sulfonyl)-2-methylene-12a-azapentadecanelactone

Base Information

Chemical Name:12a-N-((4-methoxyphenyl)sulfonyl)-2-methylene-12a-azapentadecanelactone
CAS No.:1568982-74-0
Molecular Formula:C₂₂H₃₃NO₅S
Molecular Weight:423.574
Hs Code.:

Synonyms:12a-N-((4-methoxyphenyl)sulfonyl)-2-methylene-12a-azapentadecanelactone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 12a-N-((4-methoxyphenyl)sulfonyl)-2-methylene-12a-azapentadecanelactone

Chemical Property:

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Technology Process of 12a-N-((4-methoxyphenyl)sulfonyl)-2-methylene-12a-azapentadecanelactone

There total 5 articles about 12a-N-((4-methoxyphenyl)sulfonyl)-2-methylene-12a-azapentadecanelactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1568982-50-2
2-methylene-12a-aza-pentadecanelactone hydrochloride

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 1568982-74-0
12a-N-((4-methoxyphenyl)sulfonyl)-2-methylene-12a-azapentadecanelactone

Guidance literature:: With potassium carbonate; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2013.11.032

Reference yield:

: 1568982-39-7
tert-butyloxycarbonyl-12a-azapentadecanelactone

: 1568982-74-0
12a-N-((4-methoxyphenyl)sulfonyl)-2-methylene-12a-azapentadecanelactone

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

1.2: -10 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: hydrogenchloride / diethyl ether / 20 °C

4.1: potassium carbonate / dichloromethane / 20 °C

With hydrogenchloride; potassium carbonate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.ejmech.2013.11.032

Reference yield:

: 1568982-44-4
tert-butyloxycarbonyl-2-methylene-12a-azapentadecanelactone

: 1568982-74-0
12a-N-((4-methoxyphenyl)sulfonyl)-2-methylene-12a-azapentadecanelactone

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2: hydrogenchloride / diethyl ether / 20 °C

3: potassium carbonate / dichloromethane / 20 °C

With hydrogenchloride; potassium carbonate; trifluoroacetic acid; In diethyl ether; dichloromethane;
DOI:10.1016/j.ejmech.2013.11.032