5-methyl-10,11-dihydro-5H-pyrrolo(1,2-b)(1,2,5)benzotriazepine-11-acetic acid

Base Information

Chemical Name:5-methyl-10,11-dihydro-5H-pyrrolo(1,2-b)(1,2,5)benzotriazepine-11-acetic acid
CAS No.:131967-20-9
Molecular Formula:C22H21 N3 O4
Molecular Weight:391.42
Hs Code.:
Mol file:131967-20-9.mol

Synonyms:5-methyl-10,11-dihydro-5H-pyrrolo(1,2-b)(1,2,5)benzotriazepine-11-acetic acid

Suppliers and Price of 5-methyl-10,11-dihydro-5H-pyrrolo(1,2-b)(1,2,5)benzotriazepine-11-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 4 raw suppliers

Chemical Property of 5-methyl-10,11-dihydro-5H-pyrrolo(1,2-b)(1,2,5)benzotriazepine-11-acetic acid

Chemical Property:

Vapor Pressure:5.46E-17mmHg at 25°C
Boiling Point:634.9°Cat760mmHg
Flash Point:337.8°C
PSA：75.01000
Density:1.29g/cm³
LogP:3.70240

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-methyl-10,11-dihydro-5H-pyrrolo(1,2-b)(1,2,5)benzotriazepine-11-acetic acid

There total 5 articles about 5-methyl-10,11-dihydro-5H-pyrrolo(1,2-b)(1,2,5)benzotriazepine-11-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 131925-06-9
methyl 10,11-dihydro-5-methyl-10-(4-methoxybenzoyl)-5H-pyrrolo[1,2-b][1,2,5]-benzotriazepine-11-acetate

: 131967-20-9
[9-(4-Methoxy-benzoyl)-4-methyl-9,10-dihydro-4H-3a,4,9-triaza-benzo[f]azulen-10-yl]-acetic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 18h; Ambient temperature;

Reference yield:

: 87948-04-7
N-methyl-N-(2-aminophenyl)-1H-pyrrol-1-ylamine

: 131967-20-9
[9-(4-Methoxy-benzoyl)-4-methyl-9,10-dihydro-4H-3a,4,9-triaza-benzo[f]azulen-10-yl]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / tetrahydrofuran / 15 h / Ambient temperature

2: 74 percent / POCl₃ / CH₂Cl₂ / 20 h / Heating

3: 90 percent / NaBH₃CN, HCl / ethanol; tetrahydrofuran / 20 h / Ambient temperature

4: 80 percent / Et₃N / tetrahydrofuran / 72 h / Heating

5: 87 percent / 1N aq. KOH / ethanol / 18 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; sodium cyanoborohydride; triethylamine; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 131925-03-6
Methyl 5-methyl-10,11-dihydro-5H-pyrrolo<1,2-b><1,2,5>benzotriazepine-11-acetate

: 131967-20-9
[9-(4-Methoxy-benzoyl)-4-methyl-9,10-dihydro-4H-3a,4,9-triaza-benzo[f]azulen-10-yl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / Et₃N / tetrahydrofuran / 72 h / Heating

2: 87 percent / 1N aq. KOH / ethanol / 18 h / Ambient temperature

With potassium hydroxide; triethylamine; In tetrahydrofuran; ethanol;