(R)-3-O-Benzyl-2-O-<(diethylphosphonyl)methyl>-1-O-<(p-methoxyphenyl)diphenylmethyl>glycerol

Base Information

Chemical Name:(R)-3-O-Benzyl-2-O-<(diethylphosphonyl)methyl>-1-O-<(p-methoxyphenyl)diphenylmethyl>glycerol
CAS No.:120362-28-9
Molecular Formula:C₃₅H₄₁O₇P
Molecular Weight:604.68
Hs Code.:

Synonyms:(R)-3-O-Benzyl-2-O-<(diethylphosphonyl)methyl>-1-O-<(p-methoxyphenyl)diphenylmethyl>glycerol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-O-Benzyl-2-O-<(diethylphosphonyl)methyl>-1-O-<(p-methoxyphenyl)diphenylmethyl>glycerol

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Technology Process of (R)-3-O-Benzyl-2-O-<(diethylphosphonyl)methyl>-1-O-<(p-methoxyphenyl)diphenylmethyl>glycerol

There total 8 articles about (R)-3-O-Benzyl-2-O-<(diethylphosphonyl)methyl>-1-O-<(p-methoxyphenyl)diphenylmethyl>glycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-39-0
benzyl bromide

: 120362-28-9
{1-Benzyloxymethyl-2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxymethyl}-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, 2.) DMF

2: H₂O / pTsOH / methanol / 50 °C

3: pyridine

4: 1.) NaH / 1.) THF, 2.) THF

With pyridine; water; sodium hydride; toluene-4-sulfonic acid; In methanol;
DOI:10.1016/S0040-4039(00)80790-X

Reference yield:

: 14347-83-2,15028-56-5,16495-03-7,76189-94-1
1-O-benzyl-2,3-O-isopropylidene glycerol

: 120362-28-9
{1-Benzyloxymethyl-2-[(4-methoxy-phenyl)-diphenyl-methoxy]-ethoxymethyl}-phosphonic acid diethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂O / pTsOH / methanol / 50 °C

2: pyridine

3: 1.) NaH / 1.) THF, 2.) THF

With pyridine; water; sodium hydride; toluene-4-sulfonic acid; In methanol;
DOI:10.1016/S0040-4039(00)80790-X

Reference yield:

: 17325-85-8
(2S)-3-(benzyloxy)propane-1,2-diol

: 120362-28-9
(R)-3-O-Benzyl-2-O-<(diethylphosphonyl)methyl>-1-O-<(p-methoxyphenyl)diphenylmethyl>glycerol

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 4-dimethylaminopyridine, Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

2: 1) NaH / 1) THF, a) r.t., 30 min, b) reflux, 5 h, 2) THF, a) 0 deg C, 1 h, b) r.t., 16 h

With dmap; sodium hydride; triethylamine; In dichloromethane;
DOI:10.1021/jm00127a010