5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide

Base Information

Chemical Name:5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide
CAS No.:1417658-24-2
Molecular Formula:C₁₆H₁₀ClF₆NO₂
Molecular Weight:397.704
Hs Code.:

Synonyms:5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide

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Chemical Property of 5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide

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Technology Process of 5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide

There total 4 articles about 5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 321-14-2
5-chloro-2-hydroxybenzoic acid

: 243139-67-5
4-methyl-3,5-bis(trifluoromethyl)aniline

: 1417658-24-2
5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide

Guidance literature:: With pyridine; phosphorus trichloride; In toluene; Inert atmosphere; Reflux;
DOI:10.1016/j.bmcl.2013.01.055

Reference yield: 51.0%

: 1417658-24-2
5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide

Guidance literature:: With trichlorophosphate; In toluene; for 6h; Inert atmosphere; Reflux;

Reference yield:

: 268733-18-2
4-bromo-3,5-bis(trifluoromethyl)benzenamine

: 1417658-24-2
5-chloro-2-hydroxy-N-(4-methyl-3,5-bis(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / Reflux

2: phosphorus trichloride; pyridine / toluene / Inert atmosphere; Reflux

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; phosphorus trichloride; In N,N-dimethyl-formamide; toluene; 1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmcl.2013.01.055