3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine

Base Information

Chemical Name:3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine
CAS No.:866331-13-7
Molecular Formula:C₂₆H₂₁Cl₂N₅O₈
Molecular Weight:602.387
Hs Code.:

3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O<sup>6</sup>-methyl-7-nitroguanosine

Synonyms:3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine

Suppliers and Price of 3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine

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Chemical Property of 3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine

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Technology Process of 3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine

There total 4 articles about 3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 866331-12-6
O⁶-methyl-7-deaza-7-nitro-guanine

: 21740-23-8
3,5-O-bis(4-chlorobenzoyl)-2-deoxy-α-D-ribofuranosyl chloride

: 866331-13-7
3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; acetonitrile; at 0 - 20 ℃;
DOI:10.1021/ol051144r

Reference yield:

: 866331-10-4
N-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)isobutyramide

: 866331-13-7
3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / nitric acid / 2 h / 0 °C

2: 65 percent / sodium methoxide / 8 h / Heating

3: 61 percent / NaH / dimethylformamide; various solvent(s); acetonitrile / 0 - 20 °C

With nitric acid; sodium methylate; sodium hydride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol051144r

Reference yield:

: 866331-11-5
N²-isobutyryl-6-chloro-7-deaza-7-nitro-guanine

: 866331-13-7
3',5'-bis[O-(4-chlorobenzoyl)]-7-deaza-2'-deoxy-O⁶-methyl-7-nitroguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / sodium methoxide / 8 h / Heating

2: 61 percent / NaH / dimethylformamide; various solvent(s); acetonitrile / 0 - 20 °C

With sodium methylate; sodium hydride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ol051144r