methyl 2-O-(tert-butyldimethylsilyl)-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside

Base Information

• Chemical Name: methyl 2-O-(tert-butyldimethylsilyl)-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside
• CAS No.: 603111-02-0
• Molecular Formula: C₃₅H₄₆O₆Si
• Molecular Weight: 590.832
• Mol file: 603111-02-0.mol

Synonyms:methyl 2-O-(tert-butyldimethylsilyl)-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside

Chemical Property of methyl 2-O-(tert-butyldimethylsilyl)-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-O-(tert-butyldimethylsilyl)-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside

There total 3 articles about methyl 2-O-(tert-butyldimethylsilyl)-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

methyl 3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside (34698-24-3) + tert-butyldimethylsilyl chloride (18162-48-6) → methyl 2-O-(tert-butyldimethylsilyl)-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside (603111-02-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

DOI:10.1016/S0040-4020(03)00825-1

Reference yield:

methyl beta-D-galactopyranoside (1824-94-8) → methyl 2-O-(tert-butyldimethylsilyl)-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside (603111-02-0)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂SO₄ / 20 °C

2: 10.3 g / pyridine; DMAP / 14 h / 20 °C

3: 86 percent / imidazole / dimethylformamide / 18 h / 20 °C

With pyridine; 1H-imidazole; dmap; sulfuric acid; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(03)00825-1

Reference yield:

methyl 3,4-di-O-isopropylidene-β-D-galactopyranoside (14897-47-3) → methyl 2-O-(tert-butyldimethylsilyl)-3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside (603111-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 10.3 g / pyridine; DMAP / 14 h / 20 °C

2: 86 percent / imidazole / dimethylformamide / 18 h / 20 °C

With pyridine; 1H-imidazole; dmap; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(03)00825-1

upstream raw materials:

methyl 3,4-O-isopropylidene-6-O-trityl-β-D-galactopyranoside

tert-butyldimethylsilyl chloride

methyl beta-D-galactopyranoside

methyl 3,4-di-O-isopropylidene-β-D-galactopyranoside