2-{[2-({2-[(2-ethynylphenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline

Base Information

• Chemical Name: 2-{[2-({2-[(2-ethynylphenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline
• CAS No.: 1337901-64-0
• Molecular Formula: C₃₂H₁₉N
• Molecular Weight: 417.51
• Mol file: 1337901-64-0.mol

Synonyms:2-{[2-({2-[(2-ethynylphenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline

Chemical Property of 2-{[2-({2-[(2-ethynylphenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-{[2-({2-[(2-ethynylphenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline

There total 9 articles about 2-{[2-({2-[(2-ethynylphenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-[(2-{[2-({2-[(trimethylsilyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}phenyl)ethynyl]aniline (1337901-93-5) → 2-{[2-({2-[(2-ethynylphenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline (1337901-64-0)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 2.5h;

DOI:10.1021/jo2018119

Reference yield:

2-({2-[(trimethylsilyl)ethynyl]phenyl}ethynyl)aniline (852619-15-9) → 2-{[2-({2-[(2-ethynylphenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline (1337901-64-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.5 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; 2: Sonogashira coupling;

DOI:10.1021/jo2018119

Reference yield:

2-ethynylaniline (52670-38-9) → 2-{[2-({2-[(2-ethynylphenyl)ethynyl]phenyl}ethynyl)phenyl]ethynyl}aniline (1337901-64-0)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; diisopropylamine / tetrahydrofuran / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 2.5 h / 0 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; bis(benzonitrile)palladium(II) dichloride; tri-tert-butyl phosphine; tetrabutyl ammonium fluoride; triethylamine; diisopropylamine; In tetrahydrofuran; 1: Sonogashira coupling / 3: Sonogashira coupling;

DOI:10.1021/jo2018119

upstream raw materials:

2-({2-[(trimethylsilyl)ethynyl]phenyl}ethynyl)aniline

2-[(2-ethynylphenyl)ethynyl]aniline

2-ethynylaniline

({2-[(2-bromophenyl)ethynyl]phenyl}ethynyl)trimethylsilane

Downstream raw materials:

1-phenyl-11H-benzo[a]chryseno[5,6-c]carbazole

6-[2-(phenylethynyl)phenyl]-11H-benzo[a]naphtho[2,1-c]carbazole

2-({2-[(2-{[2-(phenylethynyl)phenyl]ethynyl}phenyl)ethynyl]phenyl}ethynyl)aniline