3-(benzyloxy)-4-bromoisothiazole

Base Information

• Chemical Name: 3-(benzyloxy)-4-bromoisothiazole
• CAS No.: 930793-79-6
• Molecular Formula: C₁₀H₈BrNOS
• Molecular Weight: 270.15
• Mol file: 930793-79-6.mol

Synonyms:3-(benzyloxy)-4-bromoisothiazole

Chemical Property of 3-(benzyloxy)-4-bromoisothiazole

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 3-(benzyloxy)-4-bromoisothiazole

There total 1 articles about 3-(benzyloxy)-4-bromoisothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

3-benzyloxyisothiazole (60666-83-3) → 3-(benzyloxy)-4-bromoisothiazole (930793-79-6)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃; for 168h;

DOI:10.1039/b615162k

Reference yield: 56.0%

3-(benzyloxy)-4-bromoisothiazole (930793-79-6) + 2-(N-tert-butoxycarbonylimino)malonic acid diethyl ester (408346-61-2) → 2-(3-benzyloxy-4-bromo-5-isothiazolyl)-2-(N-tert-butoxycarbonylamino)malonic acid diethyl ester

Guidance literature:

3-(benzyloxy)-4-bromoisothiazole; With lithium diisopropyl amide; In diethyl ether; at -78 ℃; for 0.166667h;

2-(N-tert-butoxycarbonylimino)malonic acid diethyl ester; In diethyl ether; at -78 ℃; for 1h; Further stages.;

DOI:10.1039/b615162k

Reference yield: 43.0%

3-(benzyloxy)-4-bromoisothiazole (930793-79-6) + phenylacetaldehyde (122-78-1) → 1-(3-benzyloxy-4-isothiazolyl)-2-phenylethanol

Guidance literature:

3-(benzyloxy)-4-bromoisothiazole; With isopropylmagnesium chloride; In tetrahydrofuran; diethyl ether; at -30 - 0 ℃;

phenylacetaldehyde; In tetrahydrofuran; diethyl ether; at 20 ℃; Further stages.;

DOI:10.1039/b615162k

upstream raw materials:

3-benzyloxyisothiazole

Downstream raw materials:

3-benzyloxyisothiazole