60666-83-3

Basic information

• Product Name: 3-(Benzyloxy)isothiazole
• Synonyms: 3-(Benzyloxy)isothiazole
• CAS NO: 60666-83-3
• Molecular Formula: C₁₀H₉NOS
• Molecular Weight: 191.24956
• Mol File: 60666-83-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(Benzyloxy)isothiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(Benzyloxy)isothiazole(60666-83-3)
• EPA Substance Registry System: 3-(Benzyloxy)isothiazole(60666-83-3)

Safety Data

• Hazardous Substances Data: 60666-83-3(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 1003-07-2 3-hydroxyisothiazole 
• 930793-79-6 3-(benzyloxy)-4-bromoisothiazole 
• 13061-96-6 dihydroxy-methyl-borane 
• 1003-07-2 3-oxo-2,3-dihydroisothiazole 

Downstream Products

• 415724-82-2 ethyl 2-tert-butyloxycarbonylamino-2-ethoxycarbonyl-2-(3-benzyloxy-5-isothiazolyl)acetate 
• 669694-70-6 3-benzyloxy-5-iodoisothiazole 
• 930793-79-6 3-(benzyloxy)-4-bromoisothiazole 
• 930793-85-4 3-benzyloxy-4-iodoisothiazole 
• 415724-77-5 (3-benzyloxy-isothiazol-5-yl)-tert-butoxycarbonylamino-acetic acid 
• 78383-38-7 3-benzyloxy-2-methylisothiazolium fluorosulfonate 

Relevant articles and documents

TETRAHYDROPYRAZOLO-PYRAZINYL-DIHYDROIMIDAZOLONE OR TETRAHYDROPYRAZOLO-PYRIDINYL-DIHYDROIMIDAZOLONE COMPOUNDS AND METHODS OF USING SAME

The application relates to a compound of Formula (I) : or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, which modulates the activity of GLP-1 receptor, a pharmaceutical composition comprising a compound of Formula (I), and a method of treating or preventing a disease in which GLP-1 receptor plays a role.

Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: Application to the synthesis of thioibotenic acid

Direct functionalization of the 3-oxygenated isothiazole heteroaromatic parental system has not yet been reported in the literature. Here, we report the first regioselective lithiation of the 5-position of 3-(benzyloxy)isothiazole (4) using LDA in diethyl ether. The versatility of the methodology was explored by quenching with a variety of electrophiles to give the desired products 7a,b,d-g in 54-68% yield. Only benzoylation aiming at the synthesis of 7c was unsuccessful. Furthermore, a highly convergent synthesis of thioibotenic acid (1), the sulfur analogue of the neurotoxic natural product ibotenic acid, was carried out.