(2R,3R)-2-(2,4-difluorophenyl)-3-morpholinothio-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Base Information

• Chemical Name: (2R,3R)-2-(2,4-difluorophenyl)-3-morpholinothio-1-(1H-1,2,4-triazol-1-yl)-2-butanol
• CAS No.: 145942-04-7
• Molecular Formula: C₁₆H₂₀F₂N₄O₂S
• Molecular Weight: 370.423

Synonyms:(2R,3R)-2-(2,4-difluorophenyl)-3-morpholinothio-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Chemical Property of (2R,3R)-2-(2,4-difluorophenyl)-3-morpholinothio-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Chemical Property:

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Technology Process of (2R,3R)-2-(2,4-difluorophenyl)-3-morpholinothio-1-(1H-1,2,4-triazol-1-yl)-2-butanol

There total 2 articles about (2R,3R)-2-(2,4-difluorophenyl)-3-morpholinothio-1-(1H-1,2,4-triazol-1-yl)-2-butanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis<(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl> disulfide (136598-92-0) → (2R,3R)-2-(2,4-difluorophenyl)-3-morpholinothio-1-(1H-1,2,4-triazol-1-yl)-2-butanol (145942-04-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Cl₂ / CH₂Cl₂; CCl₄ / 0.33 h / 0 °C

2: CH₂Cl₂; CCl₄; toluene / 0.33 h / 0 °C

With chlorine; In tetrachloromethane; dichloromethane; toluene;

DOI:10.1248/cpb.42.85

Reference yield:

morpholine (110-91-8,99108-56-2) + C12H12ClF2N3OS (1026878-17-0) → (2R,3R)-2-(2,4-difluorophenyl)-3-morpholinothio-1-(1H-1,2,4-triazol-1-yl)-2-butanol (145942-04-7)

Guidance literature:

In tetrachloromethane; dichloromethane; toluene; at 0 ℃; for 0.333333h; Yield given;

DOI:10.1248/cpb.42.85

Reference yield: 71.0%

(2R,3R)-2-(2,4-difluorophenyl)-3-morpholinothio-1-(1H-1,2,4-triazol-1-yl)-2-butanol (145942-04-7) → (2R,3R)-2-(2,4-difluorophenyl)-3-morpholinosulfonyl-1-(1H-1,2,4-triazol-1-yl)-2-butanol

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 4h; Ambient temperature;

DOI:10.1248/cpb.42.85

upstream raw materials:

morpholine

C₁₂H₁₂ClF₂N₃OS

bis<(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl> disulfide

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