tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

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Chemical Name:tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate
CAS No.:1197291-79-4
Molecular Formula:C₃₅H₄₁FN₄O₆
Molecular Weight:632.732
Hs Code.:

Synonyms:tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

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Chemical Property of tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

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Technology Process of tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

There total 7 articles about tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1197291-78-3
4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate

: 1197291-02-3
tert-butyl (1s,4s)-4-(5-fluoro-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)nicotinamido)cyclohexylcarbamate

: 1197291-79-4
tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; In water; acetonitrile; at 70 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm5001216

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1197291-79-4
tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: water; ethanol / 78 °C / Inert atmosphere

2: triethylamine / dichloromethane / 16 h / 0 - 25 °C / Inert atmosphere

3: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate / acetonitrile; water / 2 h / 70 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; triethylamine; In ethanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jm5001216

Reference yield:

: 1196806-69-5
tert-butyl N-[(1s,4s)-4-[5-fluoro-2-(3-iodophenoxy)nicotinamido]cyclohexyl]carbamate

: 1197291-79-4
tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

2: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate / acetonitrile; water / 2 h / 70 °C / Inert atmosphere

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; palladium diacetate; potassium carbonate; In water; dimethyl sulfoxide; acetonitrile;
DOI:10.1021/jm5001216