4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate
• CAS No.: 1197291-78-3
• Molecular Formula: C₁₃H₁₄F₃NO₅S
• Molecular Weight: 353.319
• Mol file: 1197291-78-3.mol

Synonyms:4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate

Chemical Property of 4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate

There total 2 articles about 4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N,N-phenylbistrifluoromethane-sulfonimide (37595-74-7) + 4-hydroxy-3-(N-morpholinyl)methylbenzaldehyde (500859-96-1) → 4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate (1197291-78-3)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 25 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm5001216

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate (1197291-78-3)

Guidance literature:

Multi-step reaction with 2 steps

1: water; ethanol / 78 °C / Inert atmosphere

2: triethylamine / dichloromethane / 16 h / 0 - 25 °C / Inert atmosphere

With triethylamine; In ethanol; dichloromethane; water;

DOI:10.1021/jm5001216

Reference yield: 93.0%

4-formyl-2-(morpholinomethyl)phenyl trifluoromethanesulfonate (1197291-78-3) + tert-butyl (1s,4s)-4-(5-fluoro-2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)nicotinamido)cyclohexylcarbamate (1197291-02-3) → tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate (1197291-79-4)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; In water; acetonitrile; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm5001216

upstream raw materials:

4-hydroxy-benzaldehyde

N,N-phenylbistrifluoromethane-sulfonimide

4-hydroxy-3-(N-morpholinyl)methylbenzaldehyde

Downstream raw materials:

tert-butyl (1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-2'-(morpholinomethyl)biphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexylcarbamate

N-((1s,4s)-4-(2-(4'-(((3S,5R)-3,5-dimethylpiperazin-1-yl)methyl)-2'-(morpholinomethyl)biphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-4-methylthiazole-2-carboxamide trifluoroacetic acid salt

tert-butyl (1s,4s)-4-(5-fluoro-2-(4'-formyl-2'-(morpholinomethyl)biphenyl-3-yloxy)nicotinamido)cyclohexylcarbamate