2-(S)-[(2-pyridylmethyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether

Base Information

Chemical Name:2-(S)-[(2-pyridylmethyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether
CAS No.:950758-72-2
Molecular Formula:C₂₂H₂₈N₄O₃
Molecular Weight:396.489
Hs Code.:

Synonyms:2-(S)-[(2-pyridylmethyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether

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Chemical Property of 2-(S)-[(2-pyridylmethyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether

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Technology Process of 2-(S)-[(2-pyridylmethyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether

There total 7 articles about 2-(S)-[(2-pyridylmethyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1121-60-4
pyridine-2-carbaldehyde

: 950758-77-7
2-(S)-(methylamino)-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether

: 950758-72-2
2-(S)-[(2-pyridylmethyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; for 18h;
DOI:10.1039/b703835f

Reference yield:

: 950758-73-3
C₁₃H₂₁N₃O₅

: 950758-72-2
2-(S)-[(2-pyridylmethyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / LiAlH₄ / tetrahydrofuran / 18 h / Heating

2: triethylamine / CH₂Cl₂ / 18 h

3: propylamine / 2.5 h

4: 1.021 g / Cu(OAc)2 / CH₂Cl₂ / 18 h / 20 °C

5: 95 percent / cyclohexadiene / Pd/C / ethanol / 18 h

6: 99 percent / Na(OAc)3BH / 1,2-dichloro-ethane / 18 h

With propylamine; lithium aluminium tetrahydride; copper diacetate; sodium tris(acetoxy)borohydride; cyclohexa-1,3-diene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1039/b703835f

Reference yield:

: 950758-69-7
N-methyl-(L)-histidinol methyl ether

: 950758-72-2
2-(S)-[(2-pyridylmethyl)methylamino]-3-{1-[2-(methoxymethoxy)phenyl]-imidazol-4-yl}-propyl methyl ether

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / CH₂Cl₂ / 18 h

2: propylamine / 2.5 h

3: 1.021 g / Cu(OAc)2 / CH₂Cl₂ / 18 h / 20 °C

4: 95 percent / cyclohexadiene / Pd/C / ethanol / 18 h

5: 99 percent / Na(OAc)3BH / 1,2-dichloro-ethane / 18 h

With propylamine; copper diacetate; sodium tris(acetoxy)borohydride; cyclohexa-1,3-diene; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1039/b703835f