N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide

Base Information

Chemical Name:N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide
CAS No.:1180486-34-3
Molecular Formula:BrH*C₂₂H₂₃F₆N₃O₄S
Molecular Weight:620.411
Hs Code.:

Synonyms:N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide

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Chemical Property of N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide

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Technology Process of N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide

There total 9 articles about N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 474554-46-6
5,6-diethoxy-7-fluoro-3H-isoindol-1-ylamine

: 1178584-06-9
N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]acetamide

: 1180486-34-3
N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide

Guidance literature:: In tetrahydrofuran; at 7 - 25 ℃; Inert atmosphere;

Reference yield:

: 833-96-5
3-(pentafluoro-λ⁶-sulphanyl)benzoic acid

: 1180486-34-3
N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitric acid; sulfuric acid / 20 - 75 °C / Inert atmosphere

2.1: thionyl chloride / 10 h / Reflux; Inert atmosphere

3.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 - 25 °C / Inert atmosphere

4.1: hydrogen / Raney nickel / methanol / 5 h / Inert atmosphere

5.1: triethylamine / dichloromethane / 20 - 25 °C / Inert atmosphere

6.1: lithium hexamethyldisilazane / tert-butyl methyl ether; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

6.2: 0 - 25 °C / Inert atmosphere

7.1: triethylamine / dichloromethane / Inert atmosphere

8.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 7 h / 20 - 60 °C / Inert atmosphere

9.1: tetrahydrofuran / 7 - 25 °C / Inert atmosphere

With thionyl chloride; N,N-diethyl-N-isopropylamine; sulfuric acid; hydrogen; nitric acid; phenyltrimethylammonium tribromide; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether;

Reference yield:

: 852469-45-5
3-nitro-5-(pentafluoro-λ⁶-sulfanyl)benzoic acid

: 1180486-34-3
N-[3-[2-(5,6-diethoxy-7-fluoro-1-imino-1,3-dihydroisoindol-2-yl)acetyl]-5-(pentafluorosulfanyl)phenyl]acetamide hydrobromide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 10 h / Reflux; Inert atmosphere

2.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 - 25 °C / Inert atmosphere

3.1: hydrogen / Raney nickel / methanol / 5 h / Inert atmosphere

4.1: triethylamine / dichloromethane / 20 - 25 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / tert-butyl methyl ether; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

5.2: 0 - 25 °C / Inert atmosphere

6.1: triethylamine / dichloromethane / Inert atmosphere

7.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 7 h / 20 - 60 °C / Inert atmosphere

8.1: tetrahydrofuran / 7 - 25 °C / Inert atmosphere

With thionyl chloride; N,N-diethyl-N-isopropylamine; hydrogen; phenyltrimethylammonium tribromide; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; dichloromethane; tert-butyl methyl ether;