2-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-benzylacetamide

Base Information

Chemical Name:2-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-benzylacetamide
CAS No.:1351304-92-1
Molecular Formula:C₂₂H₃₆N₈O
Molecular Weight:428.581
Hs Code.:

Synonyms:2-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-benzylacetamide

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Chemical Property of 2-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-benzylacetamide

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Technology Process of 2-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-benzylacetamide

There total 3 articles about 2-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-benzylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 11-((1-(2-(benzylamino)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)-methyl)-11-aza-1,4,8-triazoniacyclotetradecane-1,4,8-triium tri-trifluoroacetate

: 1351304-92-1
2-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-benzylacetamide

Guidance literature:: With potassium hydroxide; In water; pH=11 - 12;
DOI:10.1021/ic2020012

Reference yield:

: 1351304-91-0
tri-tert-butyl 11-((1-(2-(benzylamino)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl)-1,4,8,11-tetraazacyclotetradecane-1,4,8-tricarboxylate

: 1351304-92-1
2-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-benzylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane; water / 6 h / 20 °C

2: potassium hydroxide / water / pH 11 - 12

With potassium hydroxide; In dichloromethane; water;
DOI:10.1021/ic2020012

Reference yield:

: 116433-53-5
2-azido-N-(phenylmethyl)acetamide

: 1351304-92-1
2-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-benzylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 12 h / 20 °C

2: dichloromethane; water / 6 h / 20 °C

3: potassium hydroxide / water / pH 11 - 12

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; potassium hydroxide; In dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/ic2020012