(3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate

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Chemical Name:(3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate
CAS No.:1352450-19-1
Molecular Formula:C₂F₃O₂*C₃₁H₃₁N₂O₃S
Molecular Weight:624.681
Hs Code.:

Synonyms:(3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate

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Chemical Property of (3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate

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Technology Process of (3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate

There total 5 articles about (3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: 1352565-18-4
(R)-quinuclidin-3-yl 2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetate

: 532-27-4,108321-66-0,164322-25-2
1-chloroacetophenone

: 76-05-1
trifluoroacetic acid

: 1352450-19-1
(3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate

Guidance literature:: (R)-quinuclidin-3-yl 2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetate; 1-chloroacetophenone; In ethyl acetate; at 20 ℃;

trifluoroacetic acid;

Reference yield: 26.0%

: (R)-quinuclidin-3-yl 2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetate (C₁₉)

: 532-27-4,108321-66-0,164322-25-2
1-chloroacetophenone

: 1352450-19-1
(3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate

Guidance literature:: In ethyl acetate;

Reference yield:

: 62-53-3
aniline

: 1352450-19-1
(3R)-3-(2-(benzo[b]thiophen-3-yl)-2-(phenylamino)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 1 h / 100 °C / microwave irradiation

2: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 15 h / 20 °C

3: ethyl acetate / 20 °C

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethyl acetate; acetonitrile;