2-methyl-2-(4-((3'-nitro[3,6-biquinolin]-4'-yl)amino)-phenyl)propanenitrile

Base Information

• Chemical Name: 2-methyl-2-(4-((3'-nitro[3,6-biquinolin]-4'-yl)amino)-phenyl)propanenitrile
• CAS No.: 1201646-91-4
• Molecular Formula: C₂₈H₂₁N₅O₂
• Molecular Weight: 459.507
• Mol file: 1201646-91-4.mol

Synonyms:2-methyl-2-(4-((3'-nitro[3,6-biquinolin]-4'-yl)amino)-phenyl)propanenitrile

Chemical Property of 2-methyl-2-(4-((3'-nitro[3,6-biquinolin]-4'-yl)amino)-phenyl)propanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methyl-2-(4-((3'-nitro[3,6-biquinolin]-4'-yl)amino)-phenyl)propanenitrile

There total 9 articles about 2-methyl-2-(4-((3'-nitro[3,6-biquinolin]-4'-yl)amino)-phenyl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-(4-((6-bromo-3-nitroquinolin-4-yl)amino)phenyl)-2-methylpropanenitrile (915019-51-1) + 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinoline (171364-85-5) → 2-methyl-2-(4-((3'-nitro[3,6-biquinolin]-4'-yl)amino)-phenyl)propanenitrile (1201646-91-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 100 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c5md00401b

Reference yield: 58.0%

C18H10ClN3O2 (1201646-90-3) + 2-(4-aminophenyl)-2-methylpropionitrile (115279-57-7) → 2-methyl-2-(4-((3'-nitro[3,6-biquinolin]-4'-yl)amino)-phenyl)propanenitrile (1201646-91-4)

Guidance literature:

In acetic acid; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

5-Bromo-2-aminobenzoic acid (5794-88-7) → 2-methyl-2-(4-((3'-nitro[3,6-biquinolin]-4'-yl)amino)-phenyl)propanenitrile (1201646-91-4)

Guidance literature:

Multi-step reaction with 5 steps

1: ethanol / 18 h / 20 °C

2: potassium acetate; acetic anhydride / 2 h / 120 °C

3: trichlorophosphate; N,N-dimethyl-formamide / 4 h / Reflux

4: sodium acetate; acetic acid / 0.5 h / 20 °C

5: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 8 h / 100 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium acetate; acetic anhydride; potassium carbonate; acetic acid; N,N-dimethyl-formamide; trichlorophosphate; In 1,4-dioxane; ethanol; water; 5: |Suzuki Coupling;

DOI:10.1039/c5md00401b

upstream raw materials:

C₁₈H₁₀ClN₃O₂

2-(4-aminophenyl)-2-methylpropionitrile

6-bromo-3-nitroquinolin-4-ol

6-bromo-4-chloro-3-nitroquinoline

Downstream raw materials:

2-(4-((3'-amino[3,6'-biquinolin]-4'-yl)amino)phenyl)-2-methyl propanenitrile

C₂₉H₂₁N₅

C₃₀H₂₁N₅O₂