Technology Process of 2-p-chlorophenyl-2-benzylaminocyclohexan-1-ol
There total 4 articles about 2-p-chlorophenyl-2-benzylaminocyclohexan-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide; lithium aluminium tetrahydride;
In
diethyl ether;
for 8h;
Heating;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 90 percent / Na2CO3, peracetic acid / CH2Cl2 / 4 h / 0 °C
2: 1.) NaN3, AcOH; 2.) LiAlH4; 3.) CrO3, glacial AcOH / 1.) EtOH-water, RT, 6 h; 100 deg C, 10 h; 2.) ether, reflux, 5 h; overnight; 3.) H2O, 50 deg C, 5 h
3: 98 percent / 10 percent NaOH / H2O / 1 h / 5 °C
4: 97 percent / 1.) LAH; 2.) 20percent NaOH / diethyl ether / 8 h / Heating
With
chromium(VI) oxide; peracetic acid; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; sodium carbonate; acetic acid;
In
diethyl ether; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaN3, AcOH; 2.) LiAlH4; 3.) CrO3, glacial AcOH / 1.) EtOH-water, RT, 6 h; 100 deg C, 10 h; 2.) ether, reflux, 5 h; overnight; 3.) H2O, 50 deg C, 5 h
2: 98 percent / 10 percent NaOH / H2O / 1 h / 5 °C
3: 97 percent / 1.) LAH; 2.) 20percent NaOH / diethyl ether / 8 h / Heating
With
chromium(VI) oxide; sodium hydroxide; lithium aluminium tetrahydride; sodium azide; acetic acid;
In
diethyl ether; water;
