17380-84-6

Basic information

• Product Name: 1-chloro-4-(cyclohex-1-en-1-yl)benzene
• Synonyms: 1-Chloro-4-(cyclohex-1-en-1-yl)benzene; benzene, 1-chloro-4-(1-cyclohexen-1-yl)-
• CAS NO: 17380-84-6
• Molecular Formula: C₁₂H₁₃Cl
• Molecular Weight: 192.6846
• Mol File: 17380-84-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 275°C at 760 mmHg
• Flash Point: 108.4°C
• Density: 1.108g/cm³
• Vapor Pressure: 0.00879mmHg at 25°C
• Refractive Index: 1.564
• CAS DataBase Reference: 1-chloro-4-(cyclohex-1-en-1-yl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-4-(cyclohex-1-en-1-yl)benzene(17380-84-6)
• EPA Substance Registry System: 1-chloro-4-(cyclohex-1-en-1-yl)benzene(17380-84-6)

Safety Data

• Hazardous Substances Data: 17380-84-6(Hazardous Substances Data)

Usage

Physical state

Colorless to pale yellow liquid

Uses

Intermediate in the production of pharmaceuticals and organic compounds; starting material in research studies for the synthesis of other compounds

Hazards

Skin and eye irritant; can cause respiratory and central nervous system effects if inhaled; potential environmental pollutant; can bioaccumulate in aquatic organisms

Safety measures

Proper handling and use required to minimize exposure and environmental impact.

Upstream product

• 17380-83-5 1-(4-chlorophenyl)cyclohexan-1-ol 
• 17380-85-7 N-<1-(p-Chlor-phenyl)-cyclohexyl>-formamid 
• 106-39-8 bromochlorobenzene 
• 108-94-1 cyclohexanone 
• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 637-87-6 1-Chloro-4-iodobenzene 
• 110-83-8 cyclohexene 
• 873-73-4 4-n-chlorophenylacetylene 

Downstream Products

• 829-32-3 1-chloro-4-cyclohexylbenzene 
• 61719-28-6 6-(4-chlorophenyl)-6-oxohexanenitrile 
• 56721-40-5 5-(4-Chlorobenzoyl)pentanoic acid 
• 89219-16-9 trans-1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cyclohexanol 
• 96783-51-6 2-p-chlorophenyl-2-aminocyclohexan-1-one hydrochloride 
• 96783-36-7 2-p-chlorophenyl-2-benzamidocyclohexan-1-one 
• 96783-43-6 2-p-chlorophenyl-2-benzylaminocyclohexan-1-ol 
• 227464-41-7 2-bromo-2-(4-chlorophenyl)cyclohexanone 
• 190256-59-8 2-methoxy-2-(4-chlorophenyl)cyclohexanone 

Relevant articles and documents

Grubbs Metathesis Enabled by a Light-Driven gem-Hydrogenation of Internal Alkynes

[(NHC)(cymene)RuCl2] (NHC=N-heterocyclic carbene) complexes instigate a light-driven gem-hydrogenation of internal alkynes with concomitant formation of discrete Grubbs-type ruthenium carbene species. This unorthodox reactivity mode is harnessed in the form of a “hydrogenative metathesis” reaction, which converts an enyne substrate into a cyclic alkene. The intervention of ruthenium carbenes formed in the actual gem-hydrogenation step was proven by the isolation and crystallographic characterization of a rather unusual representative of this series carrying an unconfined alkyl group on a disubstituted carbene center.

Selective one-pot carbon-carbon bond formation by catalytic boronation of unactivated cycloalkenes and subsequent coupling

(Chemical Equation Presented) Two channels: Cycloalkenes can be selectively functionalized by iridium-catalyzed boronation followed by Suzuki coupling with an aryl iodide or reaction with an aldehyde. The selectivity for allylic and vinylic functionalization can be controlled by a slight change of the reaction conditions. DBU = 1,8-diazabicyclo-[5.4.0]undec-7-ene, pin = pinacol.