(S)-5-benzyl-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-4,5-dihydro-1H-imidazol-3-ium chloride

Base Information

Chemical Name:(S)-5-benzyl-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-4,5-dihydro-1H-imidazol-3-ium chloride
CAS No.:1523535-29-6
Molecular Formula:C₂₀H₂₅N₂O*Cl
Molecular Weight:344.884
Hs Code.:

Synonyms:(S)-5-benzyl-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-4,5-dihydro-1H-imidazol-3-ium chloride

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Chemical Property of (S)-5-benzyl-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-4,5-dihydro-1H-imidazol-3-ium chloride

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Technology Process of (S)-5-benzyl-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-4,5-dihydro-1H-imidazol-3-ium chloride

There total 4 articles about (S)-5-benzyl-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-4,5-dihydro-1H-imidazol-3-ium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1523535-67-2
(S)-2-(((S)-2-(methylamino)-3-phenylpropyl)amino)-3-phenylpropan-1-ol

: 122-51-0
orthoformic acid triethyl ester

: 1523535-29-6
(S)-5-benzyl-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-4,5-dihydro-1H-imidazol-3-ium chloride

Guidance literature:: (S)-2-(((S)-2-(methylamino)-3-phenylpropyl)amino)-3-phenylpropan-1-ol; With hydrogenchloride; In methanol; diethyl ether; at 0 ℃; for 0.166667h; Inert atmosphere;

orthoformic acid triethyl ester; In toluene; at 90 ℃; for 20h; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.11.027

Reference yield:

: 3182-95-4
L-Phenylalaninol

: 1523535-29-6
(S)-5-benzyl-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-4,5-dihydro-1H-imidazol-3-ium chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.08 h / -15 °C / Inert atmosphere

1.2: 16 h / -15 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere; Reflux

3.1: hydrogenchloride / diethyl ether; methanol / 0.17 h / 0 °C / Inert atmosphere

3.2: 20 h / 90 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; isobutyl chloroformate; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/j.tetlet.2013.11.027

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 1523535-29-6
(S)-5-benzyl-3-((S)-1-hydroxy-3-phenylpropan-2-yl)-1-methyl-4,5-dihydro-1H-imidazol-3-ium chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 0.08 h / -15 °C / Inert atmosphere

1.2: 16 h / -15 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 24 h / 0 °C / Inert atmosphere; Reflux

3.1: hydrogenchloride / diethyl ether; methanol / 0.17 h / 0 °C / Inert atmosphere

3.2: 20 h / 90 °C / Inert atmosphere

With 4-methyl-morpholine; hydrogenchloride; lithium aluminium tetrahydride; isobutyl chloroformate; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/j.tetlet.2013.11.027