Methyl 1-(4-bromo-2-iodobenzyl)-4-(difluoromethyl)cyclohexanecarboxylate

Base Information

Chemical Name:Methyl 1-(4-bromo-2-iodobenzyl)-4-(difluoromethyl)cyclohexanecarboxylate
CAS No.:1383985-53-2
Molecular Formula:C₁₆H₁₈BrF₂IO₂
Molecular Weight:487.123
Hs Code.:

Synonyms:Methyl 1-(4-bromo-2-iodobenzyl)-4-(difluoromethyl)cyclohexanecarboxylate

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Chemical Property of Methyl 1-(4-bromo-2-iodobenzyl)-4-(difluoromethyl)cyclohexanecarboxylate

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Technology Process of Methyl 1-(4-bromo-2-iodobenzyl)-4-(difluoromethyl)cyclohexanecarboxylate

There total 3 articles about Methyl 1-(4-bromo-2-iodobenzyl)-4-(difluoromethyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1383985-52-1
methyl 4-(difluoromethyl)cyclohexanecarboxylate

: 885681-96-9
4-bromo-1-(bromomethyl)-2-iodobenzene

: 1383985-53-2
Methyl 1-(4-bromo-2-iodobenzyl)-4-(difluoromethyl)cyclohexanecarboxylate

Guidance literature:: methyl 4-(difluoromethyl)cyclohexanecarboxylate; With lithium diisopropyl amide; In tetrahydrofuran; n-heptane; ethylbenzene; at -78 ℃; for 1h; Inert atmosphere;

4-bromo-1-(bromomethyl)-2-iodobenzene; In tetrahydrofuran; n-heptane; ethylbenzene; at 20 ℃; for 2.5h;

Reference yield:

: 37942-76-0
4-formylcyclohexane carboxylic acid methyl ester

: 1383985-53-2
Methyl 1-(4-bromo-2-iodobenzyl)-4-(difluoromethyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 1.83 h

2.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 1 h / -78 °C / Inert atmosphere

2.2: 2.5 h / 20 °C

With (bis-(2-methoxyethyl)amino)sulfur trufluoride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene;

Reference yield:

: 13380-85-3
4-hydroxymethylcyclohexanecarboxylic acid methyl ester

: 1383985-53-2
Methyl 1-(4-bromo-2-iodobenzyl)-4-(difluoromethyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 2.5 h / 20 °C

2.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 1.83 h

3.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran; ethylbenzene / 1 h / -78 °C / Inert atmosphere

3.2: 2.5 h / 20 °C

With sodium hydrogencarbonate; Dess-Martin periodane; (bis-(2-methoxyethyl)amino)sulfur trufluoride; lithium diisopropyl amide; In tetrahydrofuran; n-heptane; dichloromethane; ethylbenzene;