13380-85-3

Basic information

• Product Name: METHYL TRANS-4-HYDROXYMETHYLCYCLOHEXANECARBOXYLATE
• Synonyms: METHYL TRANS-4-HYDROXYMETHYLCYCLOHEXANECARBOXYLATE;Cyclohexanecarboxylic acid, 4-(hydroxyMethyl)-, Methyl ester;Methyl 4-(hydroxyMethyl)cyclohexanecarboxylate
• CAS NO: 13380-85-3
• Molecular Formula: C₉H₁₆O₃
• Molecular Weight: 172.22
• Mol File: 13380-85-3.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 250.7°C at 760 mmHg
• Flash Point: 99.8°C
• Appearance: /
• Density: 1.058g/cm³
• Vapor Pressure: 0.00338mmHg at 25°C
• Refractive Index: 1.463
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
• PKA: 15.05±0.10(Predicted)
• CAS DataBase Reference: METHYL TRANS-4-HYDROXYMETHYLCYCLOHEXANECARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL TRANS-4-HYDROXYMETHYLCYCLOHEXANECARBOXYLATE(13380-85-3)
• EPA Substance Registry System: METHYL TRANS-4-HYDROXYMETHYLCYCLOHEXANECARBOXYLATE(13380-85-3)

Safety Data

• Hazardous Substances Data: 13380-85-3(Hazardous Substances Data)

Usage

Uses

Methyl 4-(Hydroxymethyl)cyclohexanecarboxylate is a useful reagent in the synthesis and biopharmaceutical evaluation of imatinib analogs.

InChI:InChI=1/C9H16O3/c1-12-9(11)8-4-2-7(6-10)3-5-8/h7-8,10H,2-6H2,1H3/t7-,8+

Upstream product

• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 13380-84-2 4-(hydroxymethyl)cyclohexane-1-carboxylic acid 
• 74-88-4 methyl iodide 
• 16940-66-2 sodium tetrahydroborate 
• 32529-79-6 4-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 67-56-1 methanol 
• 105-08-8 bis-1,4-(hydroxymethyl)cyclohexane 
• 32529-80-9 4-methoxycarbonylcyclohexanecarbonyl chloride 

Downstream Products

• 1331776-42-1 C₉H₁₅BrO₂ 
• 1003013-12-4 4-(3-nitro-pyrazol-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester 
• 1003013-13-5 4-(3-amino-pyrazol-1-ylmethyl)-cyclohexanecarboxylic acid methyl ester 

Relevant articles and documents

Synthesis of gasoline and jet fuel range cycloalkanes and aromatics from poly(ethylene terephthalate) waste

For the first time, gasoline and jet fuel range C7-C8 cycloalkanes and aromatics were selectively synthesized by the alcoholysis of poly(ethylene terephthalate) (PET) waste, followed by solvent-free hydrogenation and hydrodeoxygenation (HDO). It was found that methanol is highly reactive for the alcoholysis of PET waste. In the absence of any catalyst, a high yield of dimethyl terephthalate (97.3%) was achieved under mild conditions (473 K, 3.5 h). Dimethyl terephthalate exists as a solid and can be automatically separated from methanol with a decrease in temperature. Subsequently, dimethyl terephthalate was liquefied to dimethyl cyclohexane-1,4-dicarboxylate by hydrogenation over noble metal catalysts. Among the investigated catalysts, Pt/C exhibited the highest activity. Finally, the dimethyl cyclohexane-1,4-dicarboxylate as obtained was further hydrodeoxygenated to C7-C8 cycloalkanes and aromatics that can be used as gasoline or additives to improve the densities (or volumetric heat value) and sealabilities of current bio-jet fuels. Bimetallic Ru-Cu/SiO2 was found to be a promising HDO catalyst. According to the characterization results, the excellent HDO performance of Ru-Cu/SiO2 can be explained by the formation of smaller Ru-Cu alloy particles during the catalyst preparation. In real applications, dimethyl cyclohexane-1,4-dicarboxylate can also be simultaneously hydrodeoxygenated with biomass derived oxygenates to produce jet fuel with a suitable content of cycloalkanes and aromatics.

LACTAM COMPOUND AS FXR RECEPTOR AGONIST

Disclosed is a compound as shown in formula (I), an optical isomer thereof or a pharmaceutically acceptable salt thereof, and the present invention relates to the use of same in the preparation of a drug for treating FXR-related diseases.

Method for producing 2-hydrazinobenzothiazole derivative also providing a polymerizable composition which is useful for producing a film-like polymer

The present invention provides a novel method for producing a 2-hydrazinobenzothiazole derivative. The present invention also provides a method for producing a compound using the 2-hydrazinobenzothiazole derivative obtained by the production method, and a composition containing the compound. The present invention also provides a polymerizable composition which is useful for producing a film-like polymer and contains the compound obtained by the production method. The present invention provides a method for producing a compound represented by general formula (I-C), which comprises a step for reacting a compound represented by general formula (I-B) and a compound represented by general formula (I-A) in the presence of at least one compound selected from the group consisting of metal amides, metal hydrides, metal alkoxides and organic alkali metals; the present invention also relates to a compound derived from the compound produced by the production method and a composition containing the compound.