4790-01-6

Upstream product

• 1195-09-1 5-methyl-2-methoxyphenol 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 
• 621-59-0 isovanillin 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 

Downstream Products

• 2495-82-1 (2-Nitro-4-methoxy-5-benzyloxy-phenyl)-brenztraubensaeure 
• 131792-50-2 (RS)-1-<2-amino-5-(benzyloxy)-4-methoxybenzyl>-2-methyl-1,2,3,4-tetrahydroisoquinoline dihydrochloride 
• 131792-51-3 (RS)-9-(benzyloxy)-10-methoxyaporphine hydrochloride 
• 131792-49-9 1-<5-(benzyloxy)-4-methoxy-2-nitrobenzal>-2-methyl-1,2,3,4-tetrahydroisoquinoline 
• 2495-83-2 5-(benzyloxy)-4-methoxy-2-nitrotoluene 

Relevant academic research and scientific papers

PHENYL DERIVATIVES AS PGE2 RECEPTOR MODULATORS

The present invention relates to phenyl derivatives of formula (I) Formula (I) wherein (R1)n, R3, R4a, R4b, R5b and Ar1 are as described in the description and their use in the treatment of cancer by modulating an immune response comprising a reactivation of the immune system in the tumor. The invention further relates to novel benzofurane and benzothiophene derivatives of formula (III) and their use as pharmaceuticals, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as modulators of the prostaglandin 2 receptors EP2 and/or EP4.

The Huang-Minlon modification of Wolff-Kishner reduction in rapid and simple way using microwave technology

A high yielding, simple and fast method for the reduction of various aldehydes and ketones to the respective hydrocarbons following Huang-Minlon modification tender microwave irradiation is described.

Isomeric Monomethyl Ether Derivatives of (RS)-9,10-Dihydroxyaporphine ("Isoapomorphine") as Possible Products of Metabolism by Catechol-O-methyltransferase

The isomeric monomethyl ether derivatives of (RS)-9,10-dihydroxyaporphine ("isoapomorphine") were synthesized unequivocally as possible metabolites in catechol-O-methyltransferase (COMT) mediated O-methylation reactions.In vitro incubation studies revealed that isoapomorphine is not a substrate for the COMT using experimental conditions under which apomorphine (10,11-dihydroxyaporphine) is converted in high yield into its 10-methyl ether, apocodeine.The in vivo dopaminergic inactivity of isoapomorphine (as compared with that of apomorphine) seems to be due to factors other than metabolic inactivation by COMT.