benzvl ((2S,3R)-3-hydroxy-1-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octan-5-yl)-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:benzvl ((2S,3R)-3-hydroxy-1-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octan-5-yl)-1-oxobutan-2-yl)carbamate
CAS No.:1621483-04-2
Molecular Formula:C₂₅H₃₄N₄O₆
Molecular Weight:486.568
Hs Code.:

Synonyms:benzvl ((2S,3R)-3-hydroxy-1-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octan-5-yl)-1-oxobutan-2-yl)carbamate

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Chemical Property of benzvl ((2S,3R)-3-hydroxy-1-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octan-5-yl)-1-oxobutan-2-yl)carbamate

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Technology Process of benzvl ((2S,3R)-3-hydroxy-1-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octan-5-yl)-1-oxobutan-2-yl)carbamate

There total 7 articles about benzvl ((2S,3R)-3-hydroxy-1-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octan-5-yl)-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 1621483-03-1
(4S,5R)-benzyl 2,2,5-trimethyl-4-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro-3.4-octane-5-carbonyl)oxazolidine-3-carboxylate

: 1621483-04-2
benzvl ((2S,3R)-3-hydroxy-1-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octan-5-yl)-1-oxobutan-2-yl)carbamate

Guidance literature:: With trifluoroacetic acid; In water; at 0 - 20 ℃; for 4h;

Reference yield:

: 20266-00-6
chloroacetic acid pyrrolidide

: 1621483-04-2
benzvl ((2S,3R)-3-hydroxy-1-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octan-5-yl)-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / acetonitrile / 2 h / 0 - 20 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4: trifluoroacetic acid / water / 4 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1621483-01-9
benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate

: 1621483-04-2
benzvl ((2S,3R)-3-hydroxy-1-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octan-5-yl)-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: trifluoroacetic acid / water / 4 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water;