benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate

Base Information

Chemical Name:benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate
CAS No.:1621483-01-9
Molecular Formula:C₂₁H₂₇N₃O₄
Molecular Weight:385.463
Hs Code.:

Synonyms:benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate

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Chemical Property of benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate

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Technology Process of benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate

There total 2 articles about benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 20266-00-6
chloroacetic acid pyrrolidide

: 1621482-41-4
benzyl 6-methyl-1-oxo-2,5-diazaspiro[3.4]octane-5-carboxylate

: 1621483-01-9
benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; at 0 - 20 ℃; for 2h;

Reference yield:

: 1621482-40-3
C₂₃H₂₆N₂O₄

: 1621483-01-9
benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium cerium (IV) nitrate

2: caesium carbonate / acetonitrile / 2 h / 0 - 20 °C

With ammonium cerium (IV) nitrate; caesium carbonate; In acetonitrile;

Reference yield:

: 1621483-01-9
benzyl 6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro[3.4]octane-5-carboxylate

: 1621483-03-1
(4S,5R)-benzyl 2,2,5-trimethyl-4-(6-methyl-1-oxo-2-(2-oxo-2-(pyrrolidin-1-yl)ethyl)-2,5-diazaspiro-3.4-octane-5-carbonyl)oxazolidine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;