4-(4-chlorophenyl)-1-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-thiosemicarbazide

Base Information

• Chemical Name: 4-(4-chlorophenyl)-1-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-thiosemicarbazide
• CAS No.: 16434-24-5
• Molecular Formula: C₁₅H₁₄ClN₃O₂S
• Molecular Weight: 335.814

Synonyms:4-(4-chlorophenyl)-1-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-thiosemicarbazide

Chemical Property of 4-(4-chlorophenyl)-1-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-thiosemicarbazide

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Technology Process of 4-(4-chlorophenyl)-1-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-thiosemicarbazide

There total 4 articles about 4-(4-chlorophenyl)-1-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-(p-chlorophenyl)-3-thiosemicarbazide (22814-92-2) + vanillin (121-33-5,8014-42-4) → 4-(4-chlorophenyl)-1-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-thiosemicarbazide (16434-24-5)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.3390/molecules24173029

Reference yield: 50.0%

methyl 2-(4-hydroxy-3-methoxybenzylidene)hydrazine-1-carbodithioate (26151-89-3) + 4-chloro-aniline (106-47-8) → 4-(4-chlorophenyl)-1-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-thiosemicarbazide (16434-24-5)

Guidance literature:

In ethanol; Reflux;

DOI:10.1016/j.bmcl.2008.09.097

Reference yield:

4-Chlorophenyl isothiocyanate (2131-55-7) + vanillin (121-33-5,8014-42-4) → 4-(4-chlorophenyl)-1-[(4-hydroxy-3-methoxyphenyl)methylidene]-3-thiosemicarbazide (16434-24-5)

Guidance literature:

With hydrazine hydrate; In methanol; at 80 ℃; for 1h;

DOI:10.1016/j.bmcl.2011.02.083

upstream raw materials:

methyl 2-(4-hydroxy-3-methoxybenzylidene)hydrazine-1-carbodithioate

4-chloro-aniline

4-Chlorophenyl isothiocyanate

vanillin

Downstream raw materials:

2-(3-methoxy-4-hydroxyphenyl)-5-(4-chloro-phenylamino)-1,3,4-thiadiazole

N¹-4-chlorobenzylidene-N²-[3-(4-hydroxy-3-methoxyphenyl)-4-(2,5-dihydroxyphenyl)-1,3-thiazol-2-ylidene]hydrazine

N¹-4-chlorobenzylidene-N²-[3-(4-hydroxy-3-methoxyphenyl)-4-(1,4-benzoquinon-2-yl)-1,3-thiazol-2-ylidene]hydrazine

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