ethyl 5-benzoyl-4-methyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate

Base Information

• Chemical Name: ethyl 5-benzoyl-4-methyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate
• CAS No.: 1310804-65-9
• Molecular Formula: C₁₆H₁₄N₄O₃S
• Molecular Weight: 342.378
• Mol file: 1310804-65-9.mol

Synonyms:ethyl 5-benzoyl-4-methyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate

Chemical Property of ethyl 5-benzoyl-4-methyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-benzoyl-4-methyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate

There total 3 articles about ethyl 5-benzoyl-4-methyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 2-amino-5-benzoyl-4-methylthiophene-3-carboxylate (1310804-64-8) + orthoformic acid triethyl ester (122-51-0) → ethyl 5-benzoyl-4-methyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate (1310804-65-9)

Guidance literature:

With sodium azide; acetic acid; for 2h; Reflux;

DOI:10.1007/s00706-011-0456-z

Reference yield:

ethyl 2-cyanoacetate (105-56-6) → ethyl 5-benzoyl-4-methyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate (1310804-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur; diethylamine / ethanol / 4 h / 70 °C

2: sodium azide; acetic acid / 2 h / Reflux

With sodium azide; sulfur; acetic acid; diethylamine; In ethanol; 1: Gewald reaction;

DOI:10.1007/s00706-011-0456-z

Reference yield:

1-phenylbutan-1,3-dione (93-91-4) → ethyl 5-benzoyl-4-methyl-2-(1H-tetrazol-1-yl)thiophene-3-carboxylate (1310804-65-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur; diethylamine / ethanol / 4 h / 70 °C

2: sodium azide; acetic acid / 2 h / Reflux

With sodium azide; sulfur; acetic acid; diethylamine; In ethanol; 1: Gewald reaction;

DOI:10.1007/s00706-011-0456-z

upstream raw materials:

ethyl 2-amino-5-benzoyl-4-methylthiophene-3-carboxylate

orthoformic acid triethyl ester

ethyl 2-cyanoacetate

1-phenylbutan-1,3-dione

Downstream raw materials:

2,3-diamino-6-benzoyl-5-methylthieno[2,3-d]pyrimidin-4(3H)-one